Evidence map›Paper›PMID 32510630›Full record

ArticleJournal of cellular physiology2021

In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy.

Yingyu Chen, Jocelyn A Schroeder, Chunyan Gao, Jing Li, Jianda Hu, Qizhen Shi

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Enrichment strategies to enhance genome editing.Journal of biomedical science · 2023
    Review
  6. Review
  7. Application of Gene Therapy in Hemophilia.Current medical science · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yingyu ChenDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0003-1243-3607
Jocelyn A SchroederDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Chunyan GaoDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jing LiBlood Research Institute, Versiti Wisconsin, Milwaukee, Wisconsin.
Jianda HuDepartment of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.ORCID 0000-0002-4438-2544
Qizhen ShiDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0003-1548-0708
Fujian Medical University · CNChildren's Hospital of Wisconsin · USMedical College of Wisconsin · US

Funding

Platelet-Derived FVIII Gene Therapy of Hemophilia AR01HL102035 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Qizhen Shi · 2010 to 2026
$7.0M
NHLBI NIH HHS R01 HL102035
6 · The paper itself

Abstract

Our previous studies have demonstrated that platelet-targeted factor IX (FIX) gene therapy can introduce sustained platelet-FIX expression in hemophilia B (FIX

Indexed as

AnimalsBlood PlateletsFemaleGenetic TherapyGenetic VectorsHematopoietic Stem CellsHemophilia BImmune ToleranceLentivirusMaleMiceMice, Inbred C57BLO(6)-Methylguanine-DNA MethyltransferasePhenotypePromoter Regions, GeneticTransduction, GeneticO(6)-Methylguanine-DNA Methyltransferasedrug selectiongene therapyhemophilia Bplatelet-targeted

Identifiers

PMID32510630
PMCPMC7722216
OpenAlexW3033394393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.