Evidence map›Paper›PMID 32510326›Full record

ArticleeLife2020

CD56 regulates human NK cell cytotoxicity through Pyk2.

Justin T Gunesch, Amera L Dixon, Tasneem Am Ebrahim, Melissa M Berrien-Elliott, Swetha Tatineni, Tejas Kumar, Everardo Hegewisch-Solloa, Todd A Fehniger, Emily M Mace

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. CD33Journal for immunotherapy of cancer · 2025
    Article
  9. NK cell activity in the tumor microenvironment.Frontiers in cell and developmental biology · 2025
    Review
  10. CD56Heliyon · 2024
    Article
  11. Article
  12. Review
  13. S100A8/A9-activated IFNγCellular and molecular life sciences : CMLS · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. CD56Frontiers in immunology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Justin T GuneschBaylor College of Medicine, Houston, United States.
Amera L DixonBaylor College of Medicine, Houston, United States.
Tasneem Am EbrahimDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, United States.
Melissa M Berrien-ElliottWashington University School of Medicine, St. Louis, United States.
Swetha TatineniRice University, Houston, United States.
Tejas KumarRice University, Houston, United States.
Everardo Hegewisch-SolloaDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, United States.
Todd A FehnigerWashington University School of Medicine, St. Louis, United States.ORCID 0000-0002-8705-2887
Emily M MaceDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0003-0226-7393
Columbia University · USBaylor College of Medicine · USRice University · USWashington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Targeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
TRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4M
DEFINING THE ROLE OF CELL MIGRATION IN HUMAN NK CELL DIFFERENTIATIONR01AI137073 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MACE, EMILY MARGARET · 2018 to 2022
$2.0M
NCI NIH HHS K12 CA167540NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA205239NIAID NIH HHS R01 AI137073
6 · The paper itself

Abstract

Human natural killer (NK) cells are defined as CD56

Indexed as

CD56 AntigenCell LineCell SurvivalFocal Adhesion Kinase 2Gene DeletionGene Expression RegulationHumansKiller Cells, NaturalCD56 AntigenFocal Adhesion Kinase 2NCAM1 protein, humanPTK2B protein, humancell biologycytotoxicityhumanimmunologyinflammationinnate immunitynatural killer cellsNCAM

Identifiers

PMID32510326
PMCPMC7358009
OpenAlexW3033988359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.