ArticleeLife2020
Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 64 citations in OpenAlex.
- Schlemm's Canal Development and Implications for Glaucoma Treatment.Annual review of vision science · 2026Review
- Mechanobiology of solid tumor vasculature: implications for tumor progression.Cancer metastasis reviews · 2026Review
- Lysophosphatidic acid-mediated NF-κB activation promotes FOXC2 expression essential for lymphatic valve development.The Journal of clinical investigation · 2026Article
- Insights into KIF11 pathogenesis in microcephaly-lymphedema-chorioretinopathy syndrome from a lymphatic perspective.JCI insight · 2026Article
- The role of the cardiac lymphatic system in heart failure "reverse remodeling": from developmental signals to druggable targets.Frontiers in immunology · 2026Review
- SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes.Nucleic acids research · 2025Article
- Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips.Scientific reports · 2025Article
- Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches.PloS one · 2025Article
- Vitamin D accelerates the subdural hematoma clearance through improving the meningeal lymphatic vessel function.Molecular and cellular biochemistry · 2024Article
- Single Cell Isolation from Human Diabetic Fibrovascular Membranes for Single-Cell RNA Sequencing.Bio-protocol · 2024Article
- Fluid-Dynamic Modeling of Flow in Embryonic Tissue Indicates That Lymphatic Valve Location Is Not Consistently Determined by the Local Fluid Shear or Its Gradient.Microcirculation (New York, N.Y. : 1994) · 2024Article
- Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics.Circulation research · 2024Article
- FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation.Nature communications · 2024Article
- The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development.The Journal of clinical investigation · 2024Article
- Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation.bioRxiv : the preprint server for biology · 2024Article
- Microfluidic-Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Inactivation of ERK1/2 signaling mediates dysfunction of basal meningeal lymphatic vessels in experimental subdural hematoma.Theranostics · 2024Article
- Differential roles of FOXC2 in the trabecular meshwork and Schlemm's canal in glaucomatous pathology.Life science alliance · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Pieter R Norden *Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-5960-5245
Amélie Sabine *Department of Oncology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland.ORCID 0000-0002-7512-6703
Ying WangDepartment of Biochemistry and Molecular Biology, College of Medicine and Science, Mayo Clinic, Jacksonville, United States.ORCID 0000-0002-7852-386X
Cansaran Saygili DemirDepartment of Oncology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland.
Ting LiuFeinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States.
Tatiana V PetrovaDepartment of Oncology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland.
Tsutomu KumeFeinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-6005-5316
Northwestern University · USUniversity Hospital of Lausanne · CHJacksonville College · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MVascular Surgery Scientist Training ProgramT32HL094293 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ESKANDARI, MARK K · 2009 to 2023
$4.0MMolecular mechanisms of Foxc-mediated angiogenesisR01HL144129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2018 to 2021
$1.9MFox Transcription factors in lymphatic vessel developmentR01HL126920 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2015 to 2018
$1.5MNCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL126920NHLBI NIH HHS R01 HL144129NHLBI NIH HHS T32 HL094293
Abstract
Mutations in the transcription factor
Indexed as
AnimalsCells, CulturedEmbryo, MammalianEmbryonic DevelopmentEndothelial CellsForkhead Transcription FactorsGene Expression Regulation, DevelopmentalHumansLymphatic SystemMiceMice, KnockoutForkhead Transcription FactorsFOXC1 protein, humanFoxc1 protein, mousemesenchyme fork head 1 proteincell biologydevelopmental biologylymphatic endothelial celllymphatic valvemesenterymouse
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.