Evidence map›Paper›PMID 32510182›Full record

ArticleProteomics2020

Discovery of TBC1D7 as a Potential Driver for Melanoma Cell Invasion.

Tianyu F Qi, Lei Guo, Ming Huang, Lin Li, Weili Miao, Yinsheng Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. TBC1D2 Promotes Ovarian Cancer MetastasisFrontiers in oncology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tianyu F QiEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, 92521-0403, USA.
Lei GuoEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, 92521-0403, USA.
Ming HuangEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, 92521-0403, USA.
Lin LiEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, 92521-0403, USA.
Weili MiaoDepartment of Chemistry, University of California, Riverside, CA, 92521-0403, USA.
Yinsheng WangEnvironmental Toxicology Graduate Program, University of California, Riverside, CA, 92521-0403, USA.ORCID 0000-0001-5565-283X
University of California, Riverside · US

Funding

Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
Quantitative Adductomics Approaches for Assessing the Occurrence and Repair of DNA AdductsR01CA210072 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA210072NIEHS NIH HHS T32 ES018827NIH HHS R01 CA210072NIH HHS T32 ES018827
6 · The paper itself

Abstract

Metastasis is the leading cause for mortality in melanoma patients. Here, an unbiased mass spectrometry-based quantitative proteomic method is utilized to assess differential protein expression in a matched pair of primary/metastatic melanoma cell lines (i.e., WM-115/WM-266-4) derived from the same patient. It is found that TBC1D7 is overexpressed in metastatic over primary melanoma cells, and elevated expression of TBC1D7 promotes the invasion of these melanoma cells in vitro, partly through modulating the activities of secreted matrix metalloproteinases 2 and 9. Additionally, interrogation of publicly available data show that higher mRNA expression of TBC1D7 predicts poorer survival in melanoma patients. Together, the results suggest TBC1D7 as a driver for melanoma cell invasion, which is an important element in melanoma metastasis. The proteomic data generated from this study may also be useful for exploring the roles of other proteins in melanoma metastasis.

Indexed as

Biomarkers, TumorHumansIntracellular Signaling Peptides and ProteinsMelanomaNeoplasm InvasivenessNeoplasm MetastasisPrognosisProteomeSurvival RateBiomarkers, TumorIntracellular Signaling Peptides and ProteinsProteomeTBC1D7 protein, humanmass spectrometrymelanoma metastasisquantitative proteomicsSILACTBC1D7TBC domain-containing proteins

Identifiers

PMID32510182
PMCPMC9362880
OpenAlexW3033201523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.