Evidence map›Paper›PMID 32510037›Full record

ArticleIntegrative organismal biology (Oxford, England)2019

The Interaction of Compliance and Activation on the Force-Length Operating Range and Force Generating Capacity of Skeletal Muscle: A Computational Study using a Guinea Fowl Musculoskeletal Model.

S M Cox, K L Easton, M Cromie Lear, R L Marsh, S L Delp, J Rubenson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative organismal biology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Soft tissue constraints on joint mobility in the avian shoulder.The Journal of experimental biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. LinkingbioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. A Whole-Body Musculoskeletal Model of the Mouse.IEEE access : practical innovations, open solutions · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S M CoxBiomechanics Laboratory, Kinesiology Department, The Pennsylvania State University, University Park, PA 16802, USA.
K L EastonSchool of Human Sciences, The University of Western Australia, Perth, WA 6009, Australia.
M Cromie LearDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
R L MarshDepartment of Biology, Northeastern University, Boston, MA 02115, USA.
S L DelpDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
J RubensonBiomechanics Laboratory, Kinesiology Department, The Pennsylvania State University, University Park, PA 16802, USA.

Funding

MECHANICAL FUNCTION OF MUSCLE DURING MOVEMENTR01AR047337 · NIAMS · NORTHEASTERN UNIVERSITY · PI MARSH, RICHARD L · 2001 to 2005
$1.6M
Set for Life: Long-term Effects of Inactivity During Growth on Musculoskeletal Form and Locomotor FunctionR21AR071588 · NIAMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PIAZZA, STEPHEN J, RUBENSON, JONAS · 2018 to 2019
$365k
NIAMS NIH HHS R01 AR047337NIAMS NIH HHS R21 AR071588
6 · The paper itself

Abstract

A muscle's performance is influenced by where it operates on its force-length (F-L) curve. Here we explore how activation and tendon compliance interact to influence muscle operating lengths and force-generating capacity. To study this, we built a musculoskeletal model of the lower limb of the guinea fowl and simulated the F-L operating range during fixed-end fixed-posture contractions for 39 actuators under thousands of combinations of activation and posture using three different muscle models: Muscles with non-compliant tendons, muscles with compliant tendons but no activation-dependent shift in optimal fiber length (L0), and muscles with both compliant tendons and activation-dependent shifts in L0. We found that activation-dependent effects altered muscle fiber lengths up to 40% and increased or decreased force capacity by up to 50% during fixed-end contractions. Typically, activation-compliance effects reduce muscle force and are dominated by the effects of tendon compliance at high activations. At low activation, however, activation-dependent shifts in L0 are equally important and can result in relative force changes for low compliance muscles of up to 60%. There are regions of the F-L curve in which muscles are most sensitive to compliance and there are troughs of influence where these factors have little effect. These regions are hard to predict, though, because the magnitude and location of these areas of high and low sensitivity shift with compliance level. In this study we provide a map for when these effects will meaningfully influence force capacity and an example of their contributions to force production during a static task, namely standing.

Identifiers

PMID32510037
PMCPMC7259458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.