Evidence map›Paper›PMID 32510010›Full record

ArticleJournal of current ophthalmology

Serum 25-Hydroxyvitamin D, Selenium, Zinc and Copper in Patients with Keratoconus.

Siamak Zarei-Ghanavati, Bahareh Yahaghi, Samira Hassanzadeh, Majid Ghayour Mobarhan, Hamid Reza Hakimi, Pardis Eghbali

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Systemic and Ocular Associations of Keratoconus.Expert review of ophthalmology · 2024
    Article
  9. Article
  10. Review
  11. Observational
  12. Review
  13. Review
  14. Review
  15. Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis.Investigative ophthalmology & visual science · 2021
    Article
  16. Biochemical and molecular alterations and potential clinical applications of biomarkers in keratoconus.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Siamak Zarei-GhanavatiDepartment of Ophthalmology, Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Bahareh YahaghiDepartment of Ophthalmology, Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Samira HassanzadehDepartment of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Ghayour MobarhanDepartment of Nutrition, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamid Reza HakimiDepartment of Ophthalmology, Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Pardis EghbaliDepartment of Nutrition, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the possible association between keratoconus (KC) and serum levels of 25-hydroxyvitamin D (25OHD), Selenium (Se), Zinc (Zn), and Copper (Cu) and to compare it with age-matched healthy subjects.

methodsOne hundred patients with KC and 100 normal subjects were included. The two groups were compared for serum 25OHD and serum levels of three trace elements: Se, Zn, and Cu. These factors were also compared between groups with different KC stages.

resultsSerum levels of vitamin D, Zn, Cu, and Se were significantly different between the KC and normal groups (

conclusionLower serum 25OHD, Cu, Zn, and Se were found in the KC group compared to the control group. The results of this study suggest that a lower antioxidative activity may be involved in the possible etiology of KC.

Indexed as

CuKeratoconusSeSerum 25-hydroxyvitamin DZn

Identifiers

PMID32510010
PMCPMC7265275
OpenAlexW2979981909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.