ArticleHeliyon2020
Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats.
Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Protective effects of biogenic selenium nanoparticles synthesized by Chlorella Vulgaris against bisphenol a-induced metabolic disturbances in rats.Discover nano · 2026Article
- Selenium nanoparticles: Eco-friendly synthesis, biological activities and biomedical applications - A comprehensive review.Materials today. Bio · 2026Review
- Geltrex-based protocol for the differentiation of rat adipose tissue-derived mesenchymal stem cells into insulin-producing cells: in vitro and in vivo considerations.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Selenium-Enriched Akkermansia muciniphila: A Novel Probiotic Bacterium for Se Supplementation.Probiotics and antimicrobial proteins · 2026Article
- Acquisition of durable insulin-producing cells from human adipose tissue-derived mesenchymal stem cells as a foundation for cell- based therapy of diabetes mellitus.Scientific reports · 2024Article
- Selenium Species in Diabetes Mellitus Type 2.Biological trace element research · 2024Review
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- Article
- Selenium Nanoparticles: Green Synthesis and Biomedical Application.Molecules (Basel, Switzerland) · 2023Review
- Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model.Biological trace element research · 2023Article
- Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus.Tropical animal health and production · 2023Article
- Effect of Selenium Nanoparticles and/or Bee Venom against STZ-Induced Diabetic Cardiomyopathy and Nephropathy.Metabolites · 2023Article
- Review on the health-promoting effect of adequate selenium status.Frontiers in nutrition · 2023Review
- Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction.Environmental science and pollution research international · 2022Article
- Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles.International journal of molecular sciences · 2021Review
- Silver nanoparticles-induced nephrotoxicity in rats: the protective role of red beetroot (Beta vulgaris) juice.Environmental science and pollution research international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced diabetic rats. SeNPs were synthesized and characterized. Twenty-four albino male rats were grouped into four different groups. After the rats were induced to have type 2 diabetes by STZ, the SeNPs-treated groups received a dose of 0.5 mg/ml of SeNPs for seven days. Plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (LPO), nitric oxide (NO), glutathione peroxidase (GPx) and glutathione (GSH) were evaluated. TEM images revealed the formation of semispherical particles with average size between 40 and 50 nm. SeNPs administration successfully reduced the hyperglycemia, raised the levels of insulin in both the pancreas and the plasma and restored the damaged pancreatic tissue. SeNPs also showed enhancement of the elimination of the diabetes-induced oxidative stress injuries by decreasing the pancreatic LPO and NO levels. Furthermore, the activities of the antioxidant enzyme GPx and GSH levels of the diabetic rats were increased. In conclusion, SeNPs capped with PVP could be used in the future as an agent that could manage Diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.