Evidence map›Paper›PMID 32509773›Full record

ArticleFrontiers in cell and developmental biology2020

Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold.

Marta Cristaldi, Rodolfo Mauceri, Giuseppina Campisi, Giuseppe Pizzo, Riccardo Alessandro, Laura Tomasello, Maria Pitrone, Giuseppe Pizzolanti, Carla Giordano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Gingival Mesenchymal Stem Cells: A Periodontal Regenerative Substitute.Tissue engineering and regenerative medicine · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marta CristaldiDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Rodolfo MauceriDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Giuseppina CampisiDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Giuseppe PizzoDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Riccardo AlessandroDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Laura TomaselloDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Maria PitroneDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Giuseppe PizzolantiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Carla GiordanoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn periodontal patients with jawbone resorption, the autologous bone graft is considered a "gold standard" procedure for the placing of dental prosthesis; however, this procedure is a costly intervention and poses the risk of clinical complications. Thanks to the use of adult mesenchymal stem cells, smart biomaterials, and active biomolecules, regenerative medicine and bone tissue engineering represent a valid alternative to the traditional procedures.

aimsIn the past, mesenchymal stem cells isolated from periodontally compromised gingiva were considered a biological waste and discarded during surgical procedures. This study aims to test the osteoconductive activity of FISIOGRAFT Bone Granular MATERIALS AND

methodsWe isolated human mesenchymal stem cells from 22 healthy and 26 periodontally compromised gingival biopsy tissues and confirmed the stem cell phenotype by doubling time assay, colony-forming unit assay, and expression of surface and nuclear mesenchymal stem cell markers, respectively by cytofluorimetry and real-time quantitative PCR. Healthy and periodontally compromised gingival mesenchymal stem cells were seeded on FISIOGRAFT Bone Granular

resultsEven though preliminary, the results demonstrate that FISIOGRAFT Bone Granular

conclusionMatriderm

Indexed as

autologous bone tissue regenerationbone resorptionFISIOGRAFT Bone Granular®Matriderm®oral MSCsperiodontal diseaseperiodontally compromised GMSCswaste gingival tissue

Identifiers

PMID32509773
PMCPMC7253652
OpenAlexW3016655499

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.