Evidence map›Paper›PMID 32509742›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Development of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fields.

Yajun Zhao, Shuang Zheng, Natalie Beitel-White, Hongmei Liu, Chenguo Yao, Rafael V Davalos

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yajun ZhaoDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States.
Shuang ZhengState Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing, China.
Natalie Beitel-WhiteBioelectromechanical Systems Laboratory, Virginia Tech, Blacksburg, VA, United States.
Hongmei LiuState Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing, China.
Chenguo YaoState Key Laboratory of Power Transmission Equipment and System Security and New Technology, Chongqing University, Chongqing, China.
Rafael V DavalosDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States.
Chongqing University · CNVirginia Tech · US

Funding

Development and application of non-thermal high frequency IRE to treat hepatic tumorsR01CA240476 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVALOS, RAFAEL VIDAL · 2020 to 2024
$2.2M
NCI NIH HHS R01 CA240476
6 · The paper itself

Abstract

Pulsed electric field treatment modalities typically utilize multiple pulses to permeabilize biological tissue. This electroporation process induces conductivity changes in the tissue, which are indicative of the extent of electroporation. In this study, we characterized the electroporation-induced conductivity changes using all treatment pulses instead of solely the first pulse as in conventional conductivity models. Rabbit liver tissue was employed to study the tissue conductivity changes caused by multiple, 100 μs pulses delivered through flat plate electrodes. Voltage and current data were recorded during treatment and used to calculate the tissue conductivity during the entire pulsing process. Temperature data were also recorded to quantify the contribution of Joule heating to the conductivity according to the tissue temperature coefficient. By fitting all these data to a modified Heaviside function, where the two turning points (

Indexed as

cumulative effectdynamic processelectroporationpulsed electric fieldtissue conductivitytreatment planningtumor ablation

Identifiers

PMID32509742
PMCPMC7248411
OpenAlexW3026251579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.