ArticleTranslational vision science & technology2020
Ocular Pulse Elastography: Imaging Corneal Biomechanical Responses to Simulated Ocular Pulse Using Ultrasound.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.Translational vision science & technology · 2025Article
- Biomechanical Correlations Between the Cornea and the Optic Nerve Head.Investigative ophthalmology & visual science · 2024Article
- Three-Dimensional Ultrasound Elastography Detects Age-Related Increase in Anterior Peripapillary Sclera and Optic Nerve Head Compression During IOP Elevation.Investigative ophthalmology & visual science · 2023Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII.Investigative ophthalmology & visual science · 2022Article
- Torsional wave elastography to assess the mechanical properties of the cornea.Scientific reports · 2022Article
- Assessing corneal cross-linking with reverberant 3D optical coherence elastography.Journal of biomedical optics · 2022Article
- Multimodal Heartbeat and Compression Optical Coherence Elastography for Mapping Corneal Biomechanics.Frontiers in medicine · 2022Article
- High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade.PloS one · 2022Article
- Regional variation of corneal stromal deformation measured by high-frequency ultrasound elastography.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Heartbeat optical coherence elastography: corneal biomechanics in vivo.Journal of biomedical optics · 2021Article
- Heartbeat-Induced Corneal Axial Displacement and Strain Measured by High Frequency Ultrasound Elastography in Human Volunteers.Translational vision science & technology · 2020Article
- A review of corneal biomechanics: Mechanisms for measurement and the implications for refractive surgery.Indian journal of ophthalmology · 2020Review
- IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness.Experimental eye research · 2020Article
- Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography.Journal of biomedical optics · 2020Article
- An interferometric ex vivo study of corneal biomechanics under physiologically representative loading, highlighting the role of the limbus in pressure compensation.Eye and vision (London, England) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: In vivo evaluation of corneal biomechanics holds the potential for improving diagnosis and management of ocular diseases. We aimed to develop an ocular pulse elastography (OPE) technique to quantify corneal strains generated by naturally occurring pulsations of the intraocular pressure (IOP) using high-frequency ultrasound. Methods: Simulated ocular pulses were induced in whole porcine and human donor globes to investigate the effects of physiologic variations in baseline IOP, ocular pulse amplitude, and frequency on corneal strains. Ocular pulse-induced strains were measured in additional globes before and after UVA-riboflavin-induced corneal crosslinking. The central cornea in each eye was imaged with a 50-MHz ultrasound imaging system and correlation-based speckle tracking of radiofrequency data was used to calculate tissue displacements and strains. Results: Ocular pulse-induced corneal strains followed the cyclic changes of IOP. Both baseline IOP and ocular pulse amplitude had a significant influence on strain magnitude. Variations in pulse frequency within the normal human heart rate range did not introduce detectable changes in corneal strains. A significant decrease of corneal strain, as quantified by the OPE technique, was observed after corneal crosslinking. The extent of corneal stiffening (i.e., strain reduction) seemed to correlate with the initial strain magnitude. Conclusions: This ex vivo study demonstrated the feasibility of the OPE method to quantify corneal strains generated by IOP pulsation and detect changes associated with corneal crosslinking treatment. Translational Relevance: Integrating in vivo measurement of IOP and ocular pulse amplitude, the OPE method may lead to a new clinical tool for safe and quick biomechanical evaluations of the cornea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.