ArticleLight, science & applications2020
Common-path interferometric label-free protein sensing with resonant dielectric nanostructures.
Article in Light, science & applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Evanescent wave-based optical biosensors for innovations, medical application and future perspectives.Journal of advanced research · 2026Review
- Extreme sensitivity label-free biosensing platform based on topologically disruptive phase nano-optics.Microsystems & nanoengineering · 2026Article
- Ultrasensitive imaging-based sensor unlocked by differential guided-mode resonance.Nature communications · 2025Article
- Nanophotonic sensing and label-free imaging of extracellular vesicles.Light, science & applications · 2025Review
- Cavity Effect of Gold Nanoparticles on Mid-Infrared Light.ACS omega · 2025Article
- Resonant Young's Slit Interferometer for Sensitive Detection of Low-Molecular-Weight Biomarkers.Biosensors · 2025Article
- Review
- Information processing at the speed of light.Frontiers of optoelectronics · 2024Review
- Nano-Photonic Crystal D-Shaped Fiber Devices for Label-Free Biosensing at the Attomolar Limit of Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Label-Free Biosensor Based on Particle Plasmon Resonance Coupled with Diffraction Grating Waveguide.Sensors (Basel, Switzerland) · 2024Article
- Article
- Article
- Phase-driven progress in nanophotonic biosensing.Light, science & applications · 2024Article
- Reviewing advances in nanophotonic biosensors.Frontiers in chemistry · 2024Review
- Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials.Light, science & applications · 2024Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- Asymmetric tetramer metasurface sensor governed by quasi-bound states in the continuum.Nanophotonics (Berlin, Germany) · 2023Article
- Article
- Highly Sensitive Plasmonic Waveguide Biosensor Based on Phase Singularity-Enhanced Goos-Hänchen Shift.Biosensors · 2022Article
- BeyondACS photonics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity, low-cost, and reliable technology. Among the most sensitive modalities, interferometry offers particularly high performance, but typically lacks the required operational simplicity and robustness. Here, we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent stability. The sensor exploits the simultaneous excitation of two orthogonally polarized modes, and detects the relative phase change caused by biomolecular binding on the sensor surface. The wide dynamic range of the sensor, which is essential for fabrication and angle tolerance, as well as versatility, is controlled by integrating multiple, tuned structures in the field of view. This approach circumvents the trade-off between sensitivity and dynamic range, typical of other phase-sensitive modalities, without increasing complexity. Our sensor enables the challenging label-free detection of procalcitonin, a small protein (13 kDa) and biomarker for infection, at the clinically relevant concentration of 1 pg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.