Evidence map›Paper›PMID 32509291›Full record

ArticleJournal of global health2020

Impact of routine vaccination against

Syed Ma Zaman, Stephen Rc Howie, Magnus Ochoge, Ousman Secka, Alasana Bah, Ignatius Baldeh, Bakary Sanneh, Saffiatou Darboe, Buntung Ceesay, Haddy Bah Camara and 20 more

Open access · goldAbstract read
In one paragraph

Article in Journal of global health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 10 institutions in 8 countries.

Syed Ma ZamanMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Stephen Rc HowieMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Magnus OchogeMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Ousman SeckaMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Alasana BahMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Ignatius BaldehNational Public Health Laboratory, Ministry of Health & Social Welfare, Kotu, The Gambia.
Bakary SannehNational Public Health Laboratory, Ministry of Health & Social Welfare, Kotu, The Gambia.
Saffiatou DarboeMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Buntung CeesayMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Haddy Bah CamaraEdward Francis Small Teaching Hospital, Ministry of Health & Social Welfare, Banjul, The Gambia.
Fatme MawasNational Institute for Biological Standards and Control (NIBSC), Hertfordshire, UK.
Malick NdiayeMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Ilias HossainMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Rasheed SalaudeenMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Kalifa BojangMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Samba CeesayDirectorate of Health Services, Ministry of Health & Social Welfare, Banjul, The Gambia.
Dawda SoweDirectorate of Health Services, Ministry of Health & Social Welfare, Banjul, The Gambia.
M Jahangir HossainMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Kim MulhollandDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Brenda A Kwambana-AdamsMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Catherine OkoiMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Siaka BadjieMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Lamin CeesayExpanded Programme on Immunization, Ministry of Health & Social Welfare, Kotu, The Gambia.
Jason M MwendaWorld Health Organization, Regional Office for Africa, Brazzaville, Republic of Congo.
Adam L CohenWorld Health Organization, Headquarters, Geneva, Switzerland.
Mary AgocsAmerican Red Cross, Washington, D.C., USA.
Richard MihigoWorld Health Organization, Regional Office for Africa, Brazzaville, Republic of Congo.
Christian BottomleyMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.
Martin AntonioMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Grant A MackenzieMedical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
MRC Unit the Gambia · GMMinistry of Health and Social Welfare · GMWorld Health Organization Regional Office for Africa · CGAmerican Red Cross · USEdward Francis Small Teaching Hospital · GMLondon School of Hygiene & Tropical Medicine · GBMurdoch Children's Research Institute · AUNational Institute for Biological Standards and Control · GBUniversity of Warwick · GBWorld Health Organization · CH

Funding

Medical Research Council MC_UP_A900_1118Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

backgroundIn 1997, The Gambia introduced three primary doses of

methodsIn WCR, population-based surveillance for Hib meningitis was re-established in children aged under-10 years from 24 December 2014 to 31 March 2017, using conventional microbiology and Real Time Polymerase Chain Reaction (RT-PCR). In BHDSS, population-based surveillance for Hib disease was conducted in children aged 2-59 months from 12 May 2008 to 31 December 2017 using conventional microbiology only. Hib carriage survey was carried out in pre-school and school children from July 2015 to November 2016.

resultsIn WCR, five Hib meningitis cases were detected using conventional microbiology while another 14 were detected by RT-PCR. Of the 19 cases, two (11%) were too young to be protected by vaccination while seven (37%) were unvaccinated. Using conventional microbiology, the incidence of Hib meningitis per 100 000-child-year (CY) in children aged 1-59 months was 0.7 in 2015 (95% confidence interval (CI) = 0.0-3.7) and 2.7 (95% CI = 0.7-7.0) in 2016. In BHDSS, 25 Hib cases were reported. Nine (36%) were too young to be protected by vaccination and five (20%) were under-vaccinated for age. Disease incidence peaked in 2012-2013 at 15 per 100 000 CY and fell to 5-8 per 100 000 CY over the subsequent four years. The prevalence of Hib carriage was 0.12% in WCR and 0.38% in BHDSS.

conclusionsAfter 20 years of using three primary doses of Hib vaccine without a booster Hib transmission continues in The Gambia, albeit at low rates. Improved coverage and timeliness of vaccination are of high priority for Hib disease in settings like Gambia, and there are currently no clear indications of a need for a booster dose.

Indexed as

Meningitis, HaemophilusVaccines, ConjugateChild, PreschoolFemaleGambiaHaemophilus influenzae type bHumansImmunization ProgramsIncidenceInfantMalePrevalenceVaccines, Conjugate

Identifiers

PMID32509291
PMCPMC7243067
OpenAlexW3028556382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.