ArticleAmerican journal of translational research2020
Quercetin stimulates osteogenic differentiation of bone marrow stromal cells through miRNA-206/connexin 43 pathway.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways.Aging and disease · 2025Article
- Synthesis and Characterization of a Strontium-Quercetin Complex and Its In Vitro and In Vivo Potential for Application in Bone Regeneration.ACS omega · 2025Article
- Extraction, content determination, component analysis, and pharmacological action of Hedysari flavonoids: a review of research progress.Frontiers in pharmacology · 2025Review
- Natural Polyphenols and Mesenchymal Stem Cells: A New Insight in Bone Regenerative Medicine.Stem cells international · 2025Review
- Spatiotemporal regulation of the bone immune microenvironment via a 'ZnRegenerative biomaterials · 2025Article
- Combination of dasatinib and quercetin promotes osteogenic differentiation and stemness maintenance of hPDLSCs via YAP/TAZ.Animal cells and systems · 2025Article
- Osteoporosis: Causes, Mechanisms, Treatment and Prevention: Role of Dietary Compounds.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway.Histology and histopathology · 2024Article
- Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway.Journal of nanobiotechnology · 2024Article
- Quercetin Promotes the Repair of Mitochondrial Function in H9c2 Cells Through the miR-92a-3p/Mfn1 Axis.Current pharmaceutical biotechnology · 2024Article
- Pharmacological and mechanistic aspects of quercetin in osteoporosis.Frontiers in pharmacology · 2024Review
- Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation.International journal of molecular sciences · 2023Article
- Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss.Nutrients · 2023Review
- Chitosan/hydroxyapatite nanocomposite scaffolds to modulate osteogenic and inflammatory response.Journal of biomedical materials research. Part A · 2022Article
- Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.Frontiers in immunology · 2022Review
- Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells.Frontiers in pharmacology · 2022Review
- Lipid Nanocarriers-Loaded Nanocomposite as a Suitable Platform to Release Antibacterial and Antioxidant Agents for Immediate Dental Implant Placement Restorative Treatment.Pharmaceutics · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quantity and function of osteoblasts require continuous osteogenic differentiation of bone marrow mesenchymal stem cells. Recent evidence suggests that microRNAs (miRNAs) act as important post-transcriptional regulators in a wide range of biological processes, including osteoblastic differentiation. Quercetin has also been found to prevent bone loss. In this study, we investigated the osteogenesis of quercetin and miR-206 on bone marrow mesenchymal stem cells (BMSCs) and their relationship. We observed quercetin enhanced BMSCs proliferation with a dose-dependent manner in Cell Counting Kit-8 (CCK-8). Alizarin red S staining, alkaline phosphatase (ALP) quantification assay, miR-206 and mRNA levels of osteogenesis marker genes by quantitative real-time PCR (qPCR) were used to analyze osteogenic potential. We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN). Correspondly, Cx43 expression were increased, while miR-206 expression were decreased. In the presence of agomir of miR-206, effects of quercetin on mineralization, alkaline phosphatase activity and osteoblast-specific genes expression were suppressed. Most of all, Cx43 protein level was also blocked while overexpression of miR-206 against quercetin effects. Taken together, these data indicated that quercetin promotes BMSCs proliferation and osteogenic differentiation. The osteogenic effect of quercetin is partly modulated through miR-206/Cx43 pathway.
Indexed as
Identifiers
32509200PMC7270039W3033417357What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.