Evidence map›Paper›PMID 32509174›Full record

ArticleAmerican journal of translational research2020

Targeting and imaging colorectal cancer by activatable cell-penetrating peptides.

Ziwei Zeng, Junji Chen, Shuangling Luo, Jianghui Dong, Huanxin Hu, Zihuan Yang, Xingzhi Feng, Yiting Liu, Binbin Liu, Guangyu Pan and 3 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ziwei ZengDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Junji ChenDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Shuangling LuoDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Jianghui DongUniSA Clinical and Health Sciences, and UniSA Cancer Research Institute, University of South Australia Adelaide, SA 5001, Australia.
Huanxin HuDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Zihuan YangGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Xingzhi FengGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Yiting LiuGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Binbin LiuDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Guangyu PanState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University Nanjing 210096, Jiangsu, China.
Fiona H ZhouUniSA Clinical and Health Sciences, and UniSA Cancer Research Institute, University of South Australia Adelaide, SA 5001, Australia.
Liping WangUniSA Clinical and Health Sciences, and UniSA Cancer Research Institute, University of South Australia Adelaide, SA 5001, Australia.
Liang KangDepartment of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.
Sun Yat-sen University · CNUniversity of South Australia · AUSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While it has been a great challenge to determine the positive status of metastasis lesions, intraoperative tumor imaging, which can show tumor localization and facilitate intraoperative staging of nodal metastases, have enabled surgeons to quickly and accurately perform radical resections. However, to date, there is no accurate method for evaluating nodal status intraoperatively. In this study, we synthesized activatable cell-penetrating peptides (ACPPs) that can specifically recognize colorectal cancer and their nodal status. ACPPs were labeled with Cy5 dye at the C-terminal, and named ACPP-Cy5. Laser scanning confocal microscopy and flow cytometry were used to measure the change in intracellular fluorescence intensity between cancer cells and normal cells. The results showed while the intracellular Cy5 fluorescent intensity can be visualized in both cancer and normal cells by 8 h after adding ACPP-Cy5, the relative fluorescence intensity of colorectal cancer cells was significantly higher than the normal cells. In addition, IVIS spectrum

Indexed as

Activatable cell-penetrating peptidecolorectal cancerin vivo imagingmatrix metalloproteasereal-time imaging

Identifiers

PMID32509174
PMCPMC7270030
OpenAlexW3033223339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.