Evidence map›Paper›PMID 32509142›Full record

ArticleOxidative medicine and cellular longevity2020

Prokineticin 2 (PK2) Rescues Cardiomyocytes from High Glucose/High Palmitic Acid-Induced Damage by Regulating the AKT/GSK3

Zhen Yang, Yin Wu, Linge Wang, Peng Qiu, Wenliang Zha, Wei Yu

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  4. Regular Exercise Rescues Heart Function Defects and Shortens the Lifespan ofInternational journal of environmental research and public health · 2022
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  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen YangDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China.ORCID https://orcid.org/0000-0002-9771-6739
Yin WuDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China.
Linge WangDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China.ORCID https://orcid.org/0000-0002-3460-9792
Peng QiuDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China.
Wenliang ZhaDepartment of Surgery, Clinic Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, China.ORCID https://orcid.org/0000-0002-4827-2449
Wei YuDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China.ORCID https://orcid.org/0000-0003-1550-2946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prokineticin 2 (PK2) is a small 8 kDa protein that participates in many physiological processes, such as angiogenesis, inflammation, and neurogenesis. This experiment investigated the effect of PK2 on high glucose/high palmitic acid-induced oxidative stress, apoptosis, and autophagy in cardiomyocytes and the AKT/GSK3

Indexed as

AnimalsApoptosisAutophagosomesCell LineGastrointestinal HormonesGlucoseGlycogen Synthase Kinase 3 betaInflammationMyocytes, CardiacNeuropeptidesOxidative StressPalmitic AcidProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesSignal TransductionGastrointestinal HormonesGlucoseGlycogen Synthase Kinase 3 betaNeuropeptidesPalmitic AcidProk2 protein, ratProto-Oncogene Proteins c-aktReactive Oxygen Species

Identifiers

PMID32509142
PMCPMC7251470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.