Evidence map›Paper›PMID 32509027›Full record

ArticleBeilstein journal of organic chemistry2020

Pd-catalyzed asymmetric Suzuki-Miyaura coupling reactions for the synthesis of chiral biaryl compounds with a large steric substituent at the 2-position.

Yongsu Li, Bendu Pan, Xuefeng He, Wang Xia, Yaqi Zhang, Hao Liang, Chitreddy V Subba Reddy, Rihui Cao, Liqin Qiu

Abstract read
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In one paragraph

Article in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongsu LiSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Bendu PanSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Xuefeng HeSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Wang XiaSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Yaqi ZhangSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Hao LiangSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Chitreddy V Subba ReddySchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Rihui CaoSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.
Liqin QiuSchool of Chemistry, Guangdong Key Lab of Chiral Molecules and Drug Discovery, Sun Yat-sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China.ORCID https://orcid.org/0000-0003-1703-3530

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pd-catalyzed asymmetric Suzuki-Miyaura couplings of 3-methyl-2-bromophenylamides, 3-methyl-2-bromo-1-nitrobenzene and 1-naphthaleneboronic acids have been successfully developed and the corresponding axially chiral biaryl compounds were obtained in very high yields (up to 99%) with good enantioselectivities (up to 88% ee) under mild conditions. The chiral-bridged biphenyl monophosphine ligands developed by our group exhibit significant superiority to the naphthyl counterpart MOP in both reactivity and enantioselectivity control. The large steric hindrance from π-conjugated

Indexed as

asymmetric catalysisbiarylsmonophosphine ligandpalladium catalystSuzuki–Miyaura couplings

Identifiers

PMID32509027
PMCPMC7237804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.