Evidence map›Paper›PMID 32508963›Full record

ArticleNutrition & metabolism2020

Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity.

Naimeh Mesri Alamdari, Pardis Irandoost, Neda Roshanravan, Mohammadreza Vafa, Mohammad Asghari Jafarabadi, Shahriar Alipour, Leila Roshangar, Mohammadreza Alivand, Farnaz Farsi, Farzad Shidfar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Naimeh Mesri AlamdariDepartment of Nutrition,Student research committee, School of Health, Iran University of Medical Sciences, Tehran, Iran.
Pardis IrandoostDepartment of Nutrition,Student research committee, School of Health, Iran University of Medical Sciences, Tehran, Iran.
Neda RoshanravanCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammadreza VafaRoad Traffic Injury Prevention Research Center, School of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Asghari JafarabadiDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Shahriar AlipourStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Leila RoshangarDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammadreza AlivandColorectal Research Center, Iran University of medical sciences, Tehran, Iran.
Farnaz FarsiDepartment of Nutrition, School of Health, Iran University of Medical Sciences, Tehran, Iran.
Farzad ShidfarRoad Traffic Injury Prevention Research Center, School of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IRIran University of Medical Sciences · IRUrmia University of Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity has reached an alarming rate worldwide. Promoting thermogenesis via increasing the function of brown adipose tissue (BAT) or white adipose tissue (WAT) browning has been proposed as a new protective approach against obesity. The goal of this study was to evaluate the effects of Royal Jelly (RJ) and tocotrienol rich fraction (TRF) on BAT activation and WAT browning during calorie restriction diet (CRD) in obesity model.

methodsIn this experimental study, 50 obese Wistar rats were randomly divided into 5 groups and then received one of the following treatments for a period of 8-week: High-fat diet (HFD), CRD, RJ + CRD, TRF + CRD, and RJ + TRF + CRD. Effects of RJ and TRF, individually and in combination on body weight and the expression of key thermoregulatory genes in WAT and BAT were examined by quantitative real-time (qRT-PCR). Also, morphological alterations were assessed by hematoxylin and eosin staining.

resultsRJ (- 67.21 g ±4.84 g) and RJ + TRF (- 73.29 g ±4.51 g) significantly reduced weight gain relative to the CRD group (- 40.70 g ±6.50 g,

conclusionOur results suggest that, Royal Jelly promotes thermogenesis and browning of WAT, contributing to an increase in energy expenditure. Thus, Royal Jelly may give rise to a novel dietary choice to attenuate obesity.

Indexed as

Brown adipose tissueCalorie restrictionObesityRoyal jellyTocotrienol rich fractionWhite adipose tissue

Identifiers

PMID32508963
PMCPMC7266117
OpenAlexW3034047726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.