Evidence map›Paper›PMID 32508899›Full record

ArticleInterventional neurology2020

Predictors of Acute Neurological Worsening after Endovascular Thrombectomy.

Jazba Soomro, Liang Zhu, Sean I Savitz, Amrou Sarraj

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Early neurological deterioration as a predictor of outcomes after endovascular thrombectomy for stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Abnormal neurological pupil index is associated with malignant cerebral edema after mechanical thrombectomy in large vessel occlusion patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jazba SoomroDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Liang ZhuDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Sean I SavitzDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Amrou SarrajDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuccessful reperfusion after endovascular thrombectomy (EVT) correlates with good outcome. However, radiographic reperfusion does not always translate into good clinical outcomes even if the reperfusion occurs early after the stroke onset. Reasons for neurological worsening (NW) are thought to be many, such as progression of the stroke, hemorrhagic conversion post tissue plasminogen activator and/or EVT, and procedural complications such as vessel dissection or perforation, distal emboli, and re-occlusion. Data on patients worsening in the acute phase after EVT are limited.

objectiveWe studied the factors associated with acute NW and also identified the predictors of NW after EVT and its association with poor outcome at discharge.

methodsA retrospective cohort from a single comprehensive stroke center includes patients with acute ischemic stroke and large vessel occlusion in anterior and posterior circulation who presented between December 2014 and May 2017 and received EVT were reviewed. Primary outcome was defined as acute NW defined as change in NIHSS ≥4 from baseline in the first 24 h after EVT. Secondary outcome were modified Rankin scale (mRS) 0-2 at discharge and final infarct volume. Univariate and multivariate analyses were performed to evaluate clinical and radiographic variables independently correlating with NW after EVT. Receiver operating curve analysis was also performed to identify predictors.

results178 patients were included in the analysis, 26 (14.7%) met the criteria for acute NW. For these 178 patients, the median age was 63 (IQR 53-74, range 26-89), baseline median NIHSS was 19 (IQR 14-24, range 5-37), ASPECTS was 8 (IQR 7-9, range 4-10), admission median systolic blood pressure (SBP) was 150 (IQR 131-170, range 94-287), and initial median blood glucose (BG) was 123 (IQR 106-157, range 69-433). The most common reasons for worsening were progression of the stroke (42.3%) and reperfusion injury PH-2 (26.9%) (

conclusionOur single-center retrospective cohort result is limited by small sample size. It showed that high admission BG is an independent predictor of NW after EVT and ultimately leads to poor outcome.

Indexed as

Acute strokeAcute worseningEndovascular therapyHyperglycemiaThrombectomy

Identifiers

PMID32508899
PMCPMC7253857
OpenAlexW2951827462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.