ReviewFrontiers in plant science2020
Lysine Catabolism Through the Saccharopine Pathway: Enzymes and Intermediates Involved in Plant Responses to Abiotic and Biotic Stress.
Review in Frontiers in plant science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 99 citations in OpenAlex.
- Comparative metabolomic profiling reveals salinity tolerance mechanisms in a rice introgression line.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Lysine Biosynthesis Defines a Metabolic Checkpoint for Gibberellin-Mediated Growth in Arabidopsis thaliana.Plant, cell & environment · 2026Article
- Rhizobacteria-Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides.Plant, cell & environment · 2026Article
- Effect of Letrozole Administration on Reproductive Performance and Plasma Metabolites of Ewes During Estrus Synchronization Treatment.Life (Basel, Switzerland) · 2026Article
- Influence of Cross-Regional Cultivation on the Flavor Characteristics ofFoods (Basel, Switzerland) · 2026Article
- Comprehensive Review of L-Lysine: Chemistry, Occurrence, and Physiological Roles.Current protein & peptide science · 2026Review
- Targeting AASS alleviates neurotoxicity and improves mitochondrial function in astrocyte models for pyridoxine-dependent epilepsy.Molecular therapy. Nucleic acids · 2025Article
- Effect of exogenously applied amino acids on photosynthetic pigments, metabolites and enzymatic antioxidants in Zea mays L. subjected to salt stress.Scientific reports · 2025Article
- Metabolic Responses of Plants to Climate-Induced Stress: A Mass Spectrometry Investigation.ACS omega · 2025Article
- How drought and ploidy level shape gene expression and DNA methylation in Phragmites australis.Plant cell reports · 2025Article
- Metabolomic Profiling Identifies Key Metabolites and Defense Pathways inInternational journal of molecular sciences · 2025Article
- Effects of mycorrhizal and Trichoderma treatment on enhancing maize tolerance to salinity and drought stress, through metabolic and enzymatic evaluation.BMC plant biology · 2025Article
- Multi-omics analysis reveals the alleviating effect of oxidation remediation on tobacco quinclorac stress.Frontiers in microbiology · 2025Article
- Maize nodal root growth maintenance during water deficit: metabolic acclimation and the role of increased solute deposition in osmotic adjustment.Frontiers in plant science · 2025Article
- Marine and terrestrial biostimulant elicitors of tolerance to cold stress.Frontiers in plant science · 2025Review
- The tale of two Ions NaBMC plant biology · 2024Article
- Transcriptomic response to nitrogen availability reveals signatures of adaptive plasticity during tetraploid wheat domestication.The Plant cell · 2024Article
- Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family.Natural products and bioprospecting · 2024Article
- Toxicity of Moxifloxacin on the Growth, Photosynthesis, Antioxidant System, and Metabolism ofToxics · 2024Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The saccharopine pathway (SACPATH) involves the conversion of lysine into α-aminoadipate by three enzymatic reactions catalyzed by the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) and the enzyme α-aminoadipate semialdehyde dehydrogenase (AASADH). The LKR domain condenses lysine and α-ketoglutarate into saccharopine, and the SDH domain hydrolyzes saccharopine to form glutamate and α-aminoadipate semialdehyde, the latter of which is oxidized to α-aminoadipate by AASADH. Glutamate can give rise to proline by the action of the enzymes Δ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.