Evidence map›Paper›PMID 32508829›Full record

ReviewFrontiers in immunology2020

Nanoparticle Platforms for Antigen-Specific Immune Tolerance.

Edward B Thorp, Christian Boada, Clarens Jarbath, Xunrong Luo

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
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  4. Inhibition of CD154:CD11b interactions using a novel nanotherapeutic improves allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  5. Review
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  8. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edward B ThorpDepartments of Pathology & Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Christian BoadaDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
Clarens JarbathDepartments of Pathology & Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Xunrong LuoDivision of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.

Funding

Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
Protein-Releasing Microporous Scaffolds for Cell Replacement TherapyR01EB009910 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUO, XUNRONG, SHEA, LONNIE D · 2010 to 2018
$3.5M
TAM-Kinases in TransplantR01HL139812 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, XUNRONG, THORP, EDWARD BENJAMIN · 2018 to 2021
$2.4M
Modeling concurrent cytomegalovirus infection and transplantation toleranceR01AI114824 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, XUNRONG · 2016 to 2020
$1.4M
NHLBI NIH HHS R01 HL122309NHLBI NIH HHS R01 HL139812NIAID NIH HHS R01 AI114824NIBIB NIH HHS R01 EB009910
6 · The paper itself

Abstract

Innovative approaches in nanoparticle design have facilitated the creation of new formulations of nanoparticles that are capable of selectively calibrating the immune response. These nanomaterials may be engineered to interact with specific cellular and molecular targets. Recent advancements in nanoparticle synthesis have enabled surface functionalization of particles that mimic the diversity of ligands on the cell surface. Platforms synthesized using these design principles, called "biomimetic" nanoparticles, have achieved increasingly sophisticated targeting specificity and cellular trafficking capabilities. This holds great promise for next generation therapies that seek to achieve immune tolerance. In this review, we discuss the importance of physical design parameters including size, shape, and biomimetic surface functionalization, on the biodistribution, safety and efficacy of biologic nanoparticles. We will also explore potential applications for immune tolerance for organ or stem cell transplantation.

Indexed as

Biomimetic MaterialsNanoparticlesAnimalsAntigensDrug CompoundingGraft RejectionGraft SurvivalHumansImmunosuppressive AgentsNanomedicineOrgan TransplantationSurface PropertiesTransplantation ToleranceAntigensImmunosuppressive Agentsimmunitynanoparticlesrejectiontolerancetransplant

Identifiers

PMID32508829
PMCPMC7251028

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.