ArticleFrontiers in immunology2020
Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
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- Integrating pulmonary and systemic transcriptomes to characterize lung injury after pediatric hematopoietic stem cell transplant.JCI insight · 2025Article
- Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection.Tuberculosis (Edinburgh, Scotland) · 2025Article
- Cell-type deconvolution for bulk RNA-seq data using single-cell reference: a comparative analysis and recommendation guideline.Briefings in bioinformatics · 2024Article
- Dysfunctional bronchoalveolar effector memory CD8iScience · 2024Article
- Uncovering the Bronchoalveolar Single-Cell Landscape of Patients With Pulmonary Tuberculosis With Human Immunodeficiency Virus Type 1 Coinfection.The Journal of infectious diseases · 2024Article
- Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer's Disease via Transcriptomic Analysis.Viruses · 2024Article
- A Pilot Cross-Sectional Study of Immunological and Microbiome Profiling Reveals Distinct Inflammatory Profiles for Smokers, Electronic Cigarette Users, and Never-Smokers.Microorganisms · 2023Article
- Gene expression in TB disease measured from the periphery is different from the site of infection.Tuberculosis (Edinburgh, Scotland) · 2022Article
- Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells.Viruses · 2022Article
- Human Immunodeficiency Virus, Smoking, and Chronic Obstructive Pulmonary Disease: A Case of T Cells Stuck in the Wrong Place?American journal of respiratory cell and molecular biology · 2021Article
- Dysregulation of the Immune Environment in the Airways During HIV Infection.Frontiers in immunology · 2021Article
- Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 5 countries.
Funding
Abstract
The mechanisms by which HIV increases susceptibility to tuberculosis and other respiratory infections are incompletely understood. We used transcriptomics of paired whole bronchoalveolar lavage cells (BLCs) and peripheral blood mononuclear cells to compare the effect of HIV at the lung mucosal surface and in peripheral blood. The majority of HIV-induced differentially expressed genes (DEGs) were specific to either the peripheral or lung mucosa compartments (1,307/1,404, 93%). Type I interferon signaling was the dominant signature of DEGs in HIV-positive blood but not in HIV-positive BLCs. DEGs in the HIV-positive BLCs were significantly enriched for infiltration with cytotoxic CD8
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