ArticleFrontiers in microbiology2020
Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Enhancing the Antitumor Efficacy of Nisin Through Advanced Nanosystems: A Systematic Review of In Vitro Studies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- A comprehensive analysis of human gut microbial biosynthesis gene clusters unveiling the dominant role ofmSystems · 2025Article
- Inhibition of Clinical MRSA Isolates by Coagulase Negative Staphylococci of Human Origin.Antibiotics (Basel, Switzerland) · 2024Article
- Revisiting the Multifaceted Roles of Bacteriocins : The Multifaceted Roles of Bacteriocins.Microbial ecology · 2024Review
- An exploratoryMicrobiome research reports · 2024Review
- Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced byFrontiers in microbiology · 2024Article
- Deep learning neural network development for the classification of bacteriocin sequences produced by lactic acid bacteria.F1000Research · 2024Article
- Article
- Metagenome-mining indicates an association between bacteriocin presence and strain diversity in the infant gut.BMC genomics · 2023Article
- Demystifying Bacteriocins of Human Microbiota by Genome Guided Prospects: An Impetus to Rekindle the Antimicrobial Research.Current protein & peptide science · 2022Review
- Correlation between type IIIA CRISPR-Cas system and SCCmec in Staphylococcus epidermidis.Archives of microbiology · 2021Article
- The microbiome-shaping roles of bacteriocins.Nature reviews. Microbiology · 2021Review
- Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum.Metabolic engineering · 2021Article
- Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides.Angewandte Chemie (International ed. in English) · 2021Article
- The Relationship Between Breast Milk Components and the Infant Gut Microbiota.Frontiers in nutrition · 2021Review
- Targeted Genome Mining Reveals the PsychrophilicFrontiers in microbiology · 2021Article
- Molecular Characterization of Microbiota in Cerebrospinal Fluid From Patients With CSF Shunt Infections Using Whole Genome Amplification Followed by Shotgun Sequencing.Frontiers in cellular and infection microbiology · 2021Article
- The Microbiota of the Human Mammary Ecosystem.Frontiers in cellular and infection microbiology · 2020Review
- Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial colonization of the infant gut is a convoluted process dependent on numerous contributing factors, including age, mode of delivery and diet among others that has lifelong implication for human health. Breast milk also contains a microbiome which acts as a source of colonizing bacteria for the infant. Here, we demonstrate that human milk harbors a wide diversity of bacteriocin-producing strains with the potential to compete among the developing gut microbiota of the infant. We screened 37 human milk samples and found isolates with antimicrobial activity and distinct cross-immunity profiles. From these isolates, we detected 73 putative gene clusters for bacteriocins of all known sub-classes, including 16 novel prepeptides. More specifically, we detected two novel lantibiotics, four sactibiotics and three class IIa bacteriocins with an unusual modification of the pediocin box that is composed of YDNGI instead of the highly conserved motif YGNGV. Moreover, we identified a novel class IIb bacteriocin, four novel class IIc and two class IId bacteriocins. In conclusion, human milk contains a variety of bacteriocin-producing strains which may provide them a competitive advantage in the colonization of the infant gut and suggests that the milk microbiota is a source of antimicrobial potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.