Evidence map›Paper›PMID 32508669›Full record

ArticleFrontiers in physiology2020

Metformin Ameliorates Diabetic Cardiomyopathy by Activating the PK2/PKR Pathway.

Zhen Yang, Min Wang, Yuchen Zhang, Fei Cai, Botao Jiang, Wenliang Zha, Wei Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  17. The Protective Effect of Sheng Mai Yin on Diabetic Cardiomyopathy via NLRP3/Caspase-1 Pathway.Evidence-based complementary and alternative medicine : eCAM · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhen YangDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, China.
Min WangDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, China.
Yuchen ZhangDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, China.
Fei CaiHubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, China.
Botao JiangDepartment of Urology, Xianning Central Hospital, Xianning, China.
Wenliang ZhaDepartment of Surgery, Clinic Medical College, Hubei University of Science and Technology, Xianning, China.
Wei YuDepartment of Pharmacology, School of Pharmacy, Hubei University of Science and Technology, Xianning, China.
Hubei University of Science and Technology · CNXianning Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) is a complication of diabetes that can cause damage to myocardial structure and function. Metformin (Met) is a widely used type 2 diabetes treatment drug that exerts cardioprotective effects through multiple pathways. Prokineticin 2 (PK2) is a small-molecule secreted protein that plays pivotal parts in cardiomyocyte survival and angiogenesis. However, the role of Met in regulating the PK2 signaling pathway in DCM remains unclear. This experiment explored the effects of Met on high glucose (HG)-induced injury through the PK2/PKR pathway

Indexed as

AKT/GSK3β signaling pathwayapoptosisdiabetic cardiomyopathyprokineticin 2prokineticin 2 receptors

Identifiers

PMID32508669
PMCPMC7252307
OpenAlexW3027682154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.