ArticleFrontiers in physiology2020
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 39 citations in OpenAlex.
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Three-week dry immersion results in a more severe impairment of cardiac baroreflex than head-down bed rest of the same duration.European journal of applied physiology · 2026Article
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.NPJ microgravity · 2026Article
- Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles.NPJ microgravity · 2025Article
- Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest.NPJ microgravity · 2025Article
- Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.Military Medical Research · 2024Review
- Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.Science advances · 2023Article
- Changes in the body fluids proteome as a reflection of the physiological effects of dry immersion.Frontiers in physiology · 2023Article
- Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- The Cardiovascular System in Space: Focus on In Vivo and In Vitro Studies.Biomedicines · 2021Review
- 4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement.NPJ microgravity · 2021Article
- The First Female Dry Immersion (NAIAD-2020): Design and Specifics of a 3-Day Study.Frontiers in physiology · 2021Article
- Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most applicable human models of weightlessness are -6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately.
objectivesWe compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by -6° HDBR and DI.
methodsEleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill-Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80° lower body negative pressure-tilt test was conducted before and right after both exposures.
resultsFor most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI.
conclusionsIn general, cardiovascular changes during the 21-day HDBR and 3-day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness).
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