SynthesisFrontiers in pharmacology2020
Antidepressant Use in Depressed Women During Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis of 23 Cohort Studies.
Synthesis in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Safety of psychotropic medications in pregnancy: an umbrella review.Molecular psychiatry · 2025Pooled it
- Identifying and synthesizing components of perinatal mental health peer support - a systematic review.Frontiers in psychiatry · 2024Pooled it
- Cognitive Behavioral Therapy for Individuals With Low Literacy and Perinatal Depression: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Sertraline use in pregnancy and placental transfer: A pharmacokinetic prospective cohort study.Pregnancy (Hoboken, N.J.) · 2025Article
- Prenatal treatment with the antidepressant fluoxetine on maternal and neonatal behavior in sheep.Pediatric research · 2025Article
- Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2024Article
- Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring.Journal of clinical medicine · 2024Review
- Article
- Article
- Consensus Panel Recommendations for the Pharmacological Management of Pregnant Women with Depressive Disorders.International journal of environmental research and public health · 2023Article
- Maternal serotonin: implications for the use of selective serotonin reuptake inhibitors during gestation†.Biology of reproduction · 2023Review
- Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users.Pharmacotherapy · 2023Article
- Study of the Mechanisms and Therapeutic Approaches of Migraine in Women and Pregnancy: A Literature Review.Cureus · 2023Review
- Contemporary management of unipolar depression in the perinatal period.Expert review of neurotherapeutics · 2021Article
- Antepartum Depression and Preterm Birth: Pathophysiology, Epidemiology, and Disparities due to structural racism.Current psychiatry reports · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe associations between maternal use of antidepressant during pregnancy and preterm birth (PTB) has been the subject of much discussion and controversy. The aim of the present study was to systematically review the association between antidepressant use during pregnancy and the risk of PTB, especially in depressed women.
methodsA computerized search was conducted in PubMed, PsycINFO, and Embase before
resultsA total of 2,279 articles were reviewed, 23 of which were selected. The risk of PTB was increased in women with depression [1.58 (1.23-2.04)] and in the general pregnant female population [1.35 (1.11-1.63)] who used antidepressants during pregnancy. Similar results were observed in depressed women treated with selective serotonin reuptake inhibitors (SSRIs) during pregnancy [1.46 (1.32-1.61)]. There was no significantly increased risk of PTB observed with SSRI use in the general pregnant female population [1.25 (1.00-1.57)], and the heterogeneity of these studies was high.
conclusionsThe results of this meta-analysis indicate maternal antidepressant use is associated with a significantly increased risk of PTB in infants. Health care providers and pregnant women must weigh the risk-benefit potential of these drugs when making decisions about whether to treat with antidepressant during pregnancy.
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