ReviewFrontiers in systems neuroscience2020
The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging.
Review in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Functional Ultrasound Localization Microscopy on Freely Moving Rats.Research square · 2026Article
- Kainic acid pig model of hippocampal epilepsy.Scientific reports · 2026Article
- Integration of resting-state and stimulus-fMRI uncovers reduced network flexibility in post-surgical pain.Scientific reports · 2026Article
- Effects of an orexin receptor 2-selective agonist on salivary secretion in rats.Scientific reports · 2026Article
- Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Article
- Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice.bioRxiv : the preprint server for biology · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Advanced preclinical functional magnetic resonance imaging of the brain.Npj imaging · 2025Review
- Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo.Neurochemical research · 2025Review
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The impact of isoflurane anesthesia on brain metabolism in mice: An MRI and electroencephalography study.NMR in biomedicine · 2024Article
- Parabrachial nucleus Vglut2 expressing neurons projection to the extended amygdala involved in the regulation of wakefulness during sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2024Article
- The mouse motor system contains multiple premotor areas and partially follows human organizational principles.Cell reports · 2024Article
- Article
- Article
- Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A consensus protocol for functional connectivity analysis in the rat brain.Nature neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In recent years, technical and procedural advances have brought functional magnetic resonance imaging (fMRI) to the field of murine neuroscience. Due to its unique capacity to measure functional activity non-invasively, across the entire brain, fMRI allows for the direct comparison of large-scale murine and human brain functions. This opens an avenue for bidirectional translational strategies to address fundamental questions ranging from neurological disorders to the nature of consciousness. The key challenges of murine fMRI are: (1) to generate and maintain functional brain states that approximate those of calm and relaxed human volunteers, while (2) preserving neurovascular coupling and physiological baseline conditions. Low-dose anesthetic protocols are commonly applied in murine functional brain studies to prevent stress and facilitate a calm and relaxed condition among animals. Yet, current mono-anesthesia has been shown to impair neural transmission and hemodynamic integrity. By linking the current state of murine electrophysiology, Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.