Evidence map›Paper›PMID 32508455›Full record

ArticleJournal of oral and maxillofacial pathology : JOMFP

Effect of

M Harsha, K P Mohan Kumar, Santosh Kagathur, Vikram S Amberkar

Open access · greenAbstract read
In one paragraph

Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Bioactive compound identification without fractionation: an Ocimum spp. case study.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
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  4. Inhibitory Potential of theMolecules (Basel, Switzerland) · 2023
    Article
  5. An Update on the Therapeutic Anticancer Potential ofMolecules (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Structure-Based In Silico Investigation of Agonists for Proteins Involved in Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M HarshaDepartment of Oral Pathology, Lenora Institute of Dental Sciences, Rajanagaram, Andhra Pradesh, India.
K P Mohan KumarDepartment of Oral Pathology and Microbiology, College of Dental Sciences, Davangere, Karnataka, India.
Santosh KagathurDepartment of Internal Medicine, Brandon Regional Hospital, Brandon, FL, USA.
Vikram S AmberkarDepartment of Oral Pathology and Microbiology, College of Dental Sciences, Davangere, Karnataka, India.
Bapuji Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurge of cancer incidence, effects of chemotherapeutic agents and their cost and reduced survival and responsiveness to treatment have led to shift of attention of researchers toward herbal remedies to look for newer dimension in cancer therapy. MATERIALS AND

methodsDry and aqueous extracts of two types of Tulsi leaves (Rama Tulsi and Krishna Tulsi) were evaluated for a dose-dependent cytotoxicity and anti-proliferative against K562 cell lines, leukoerythroid progenitor leukemic cell lines by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Half-maximal inhibitory concentration was evaluated for each of the extracts.

resultsBoth dry and aqueous extracts of both types of Tulsi leaves demonstrated a significant amount of cytotoxicity against the studied cell lines.

conclusionThis being preliminary study, we propose the initial finding of cytotoxic abilities of the herb against the leukemic cell lines and recommend a more detailed evaluation of the herb and its components.

Indexed as

3-(4,5-Dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assayapoptosiscytotoxicityK562 cell linesKrishna TulsiOcimum sanctumRama TulsiTulsi

Identifiers

PMID32508455
PMCPMC7269281
OpenAlexW3023419720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.