Evidence map›Paper›PMID 32508238›Full record

ArticleRNA biology2020

Pituitary miRNAs target GHRHR splice variants to regulate GH synthesis by mediating different intracellular signalling pathways.

Yunyun Cheng, Ting Chen, Jie Song, Zhaohui Teng, Chunli Wang, Siyao Wang, Guanhong Lu, Tianqi Feng, Qien Qi, Qianyun Xi and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Growth hormone-releasing hormone receptor (GHRH-R) and its signaling.Reviews in endocrine & metabolic disorders · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yunyun ChengJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Ting ChenGuangdong Provincial Key Laboratory of Animal Nutritional Regulation, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou, China.
Jie SongJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Zhaohui TengJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Chunli WangJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Siyao WangJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Guanhong LuJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.ORCID 0000-0002-4289-1134
Tianqi FengJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Qien QiSchool of Life Science and Engineering, Foshan University , Foshan China.
Qianyun XiGuangdong Provincial Key Laboratory of Animal Nutritional Regulation, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou, China.
Songcai LiuJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Linlin HaoJilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University , Changchun, China.
Yongliang ZhangGuangdong Provincial Key Laboratory of Animal Nutritional Regulation, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University , Guangzhou, China.
Jilin University · CNSouth China Agricultural University · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth hormone (GH), whose synthesis and release are mainly regulated by intracellular signals mediated by growth hormone-releasing hormone receptor (GHRHR), is one of the major pituitary hormones and critical regulators of organism growth, metabolism, and immunoregulation. Pig GHRHR splice variants (SVs) may activate different signalling pathways via the variable C-terminal by alternative splicing, and SVs have the potential to change microRNA (miRNA) binding sites. In this study, we first confirmed the existence of pig GHRHR SVs (i.e., GHRHR, GHRHR SV1 and SV2) and demonstrated the inhibitory effects of critical pituitary miRNAs (i.e., let-7e and miR-328-5p) on GH synthesis and cell proliferation of primary pituitary cells. The SVs of

Indexed as

Alternative SplicingRNA InterferenceSignal TransductionAnimalsCell LineCell ProliferationCell SurvivalComputational BiologyFemaleGene Expression ProfilingGene Expression RegulationGrowth HormoneMicroRNAsNitric OxidePituitary GlandReceptors, Pituitary Hormone-Regulating HormoneGrowth HormoneMicroRNAsNitric OxideReceptors, Pituitary Hormone-Regulating HormoneGHRHRgrowth hormone synthesismiRNApituitarysplice variants

Identifiers

PMID32508238
PMCPMC7714533
OpenAlexW3033137056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.