Evidence map›Paper›PMID 32508185›Full record

ArticleJournal of the American Heart Association2020

O-GlcNAcylation Mediates Glucose-Induced Alterations in Endothelial Cell Phenotype in Human Diabetes Mellitus.

Nobuyuki Masaki, Bihua Feng, Rosa Bretón-Romero, Elica Inagaki, Robert M Weisbrod, Jessica L Fetterman, Naomi M Hamburg

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

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  10. O-GlcNAc modulation of nuclear pore complexes orchestrates mRNA export efficiency.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  20. Molecular Basis of Cardiomyopathies in Type 2 Diabetes.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nobuyuki MasakiThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Bihua FengThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Rosa Bretón-RomeroThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Elica InagakiThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Robert M WeisbrodThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Jessica L FettermanThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Naomi M HamburgThe Whitaker Cardiovascular Institute Department of Medicine Boston University School of Medicine Boston MA.
Boston University · US

Funding

Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2005 to 2015
$21.5M
Mitochondrial Dynamics and UCP2 - Endothelial Dysfunction in Human ObesityR01HL115391 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2013 to 2017
$2.8M
Endothelial Insulin Resistance, Inflammation and Vascular Function in DiabetesR01HL102299 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM · 2010 to 2014
$2.0M
Relations of Mitochondrial Genetic Variation and Function with Atrial FibrillationK01HL143142 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FETTERMAN, JESSICA L · 2019 to 2023
$757k
NHLBI NIH HHS K01 HL143142NHLBI NIH HHS P01 HL081587NHLBI NIH HHS R01 HL102299NHLBI NIH HHS R01 HL115391
6 · The paper itself

Abstract

Background Posttranslational protein modification with O-linked

Indexed as

Adultbeta-N-AcetylhexosaminidasesCase-Control StudiesCells, CulturedDiabetes Mellitus, Type 2Endothelial CellsFemaleForearmGlucoseGlycosylationHumansInsulinMaleMiddle AgedNitric Oxide Synthase Type IIIPhenotypebeta-N-AcetylhexosaminidasesGlucosehexosaminidase CInsulinNitric Oxide Synthase Type IIINOS3 protein, humandiabetes mellitusendothelial nitric oxide synthaseinsulin resistanceO‐GlcNAc

Identifiers

PMID32508185
PMCPMC7429031
OpenAlexW3033984139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.