Observational studyGeneral thoracic and cardiovascular surgery2020
Hypothermic circulatory arrest induced coagulopathy: rotational thromboelastometry analysis.
Observational study in General thoracic and cardiovascular surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Systemic hypothermia in non-aortic cardiac surgery: a narrative review.Journal of thoracic disease · 2026Review
- Organ protection via core temperature control in Type A aortic dissection using pure hypothermia alone.Journal of cardiothoracic surgery · 2026Article
- Aortic Arch and Frozen Elephant Trunk Surgery: Anesthetic Challenges and Strategies for Organ Protection.Journal of clinical medicine · 2026Review
- Innovative strategies in coagulation management for cardiothoracic surgery: a narrative review of pharmacological and nonpharmacological approaches.Journal of cardiothoracic surgery · 2025Review
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Impact of Cooling Strategies on Transfusion Requirements in Aortic Hemiarch Surgery.Aorta (Stamford, Conn.) · 2025Article
- Hypothermic circulatory arrest at 20 ℃ does not deteriorate coagulopathy compared to 28 ℃ in a pig model.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Anesthetic Management for Proximal Aortic Repair.Seminars in cardiothoracic and vascular anesthesia · 2025Review
- A LASSO-derived model for the prediction of coagulation disorders after coronary artery bypass grafting.Journal of thoracic disease · 2025Article
- Optimization of Hypothermic Protocols for Neurocognitive Preservation in Aortic Arch Surgery: A Literature Review.Journal of cardiovascular development and disease · 2024Review
- Open aortic arch repair without circulatory arrest by frozen elephant trunk in Ishimaru zone 0.Journal of cardiothoracic surgery · 2024Article
- Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting.Brazilian journal of cardiovascular surgery · 2023Article
- A Strategy for Minimizing Circulatory Arrest Duration in Complex Aortic Arch Procedures.Medicina (Kaunas, Lithuania) · 2023Observational
- Hypothermic circulatory arrest does not induce coagulopathy in vitro.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Association between Functional Parameters of Coagulation and Conventional Coagulation Tests in the Setting of Fluid Resuscitation with Balanced Crystalloid or Gelatine: A Secondary Analysis of an In Vivo Prospective Randomized Crossover Study.Journal of clinical medicine · 2022Article
- In Vivo Effects of Balanced Crystalloid or Gelatine Infusions on Functional Parameters of Coagulation and Fibrinolysis: A Prospective Randomized Crossover Study.Journal of personalized medicine · 2022Article
- Which factors have a great impact on coagulopathy and hemostatic impairment after cardiopulmonary bypass in cardiovascular surgery? An analysis based on rotational thromboelastometry.General thoracic and cardiovascular surgery · 2022Article
- The David Operation Offers Shorter Hemostasis Time Than the Bentall in Case of Acute Aortic Dissection Type A.Cureus · 2022Article
- Recombinant Activated Factor VII in Aortic Surgery for Patients Under Hypothermic Circulatory Arrest.Therapeutics and clinical risk management · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHypothermic circulatory arrest (HCA) has been considered to cause coagulopathy during cardiac surgery. However, coagulopathy associated with HCA has not been understood clearly in details. The objective of this study is to analyze the details of coagulopathy related to HCA in cardiac surgery by using rotational thromboelastometry (ROTEM).
methodsWe retrospectively analyzed 38 patients who underwent elective cardiac surgery (HCA group = 12, non-HCA group = 26) in our hospital. Blood samples were collected before and after cardiopulmonary bypass (CPB). Standard laboratory tests (SLTs) and ROTEM were performed. We performed four ROTEM assays (EXTEM, INTEM, HEPTEM and FIBTEM) and analyzed the following ROTEM parameters: clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and maximum clot elasticity (MCE). The amount of perioperative bleeding, intraoperative transfusion and perioperative data were compared between the HCA and non-HCA group.
resultsOperation time and hemostatic time were significantly longer in the HCA group, whereas CPB time had no difference between the groups. The amount of perioperative bleeding and intraoperative transfusion were much higher in the HCA group. SLTs showed no difference between the groups both after anesthesia induction and after protamine reversal. In ROTEM analysis, MCE contributed by platelet was reduced in the HCA group, whereas MCE contributed by fibrinogen had no difference.
conclusionOur study confirmed that the amount of perioperative bleeding and intraoperative transfusion were significantly higher in the HCA group. ROTEM analysis would indicate that clot firmness contributed by platelet component is reduced by HCA in cardiac surgery.
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