ArticleMolecular diversity2021
Urease: a highly efficient biocatalyst for synthesis of polyhydroquinolines and polyhydroacridines from the ammonia formed in situ.
Article in Molecular diversity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- Doughnut-like wrinkled fibrous nano silica architecture as a novel and effective reusable green heterogeneous nanocatalyst for the Hantzsch reaction.Scientific reports · 2025Article
- Design of natural asphalt sulfamic acid (NA-NHSOHeliyon · 2025Article
- DABCO-modified magnetic core-shell as an efficient nanocatalyst for synthesizing polyhydroquinoline derivatives.Frontiers in chemistry · 2025Article
- Prospects of formamide as nitrogen source in biotechnological production processes.Applied microbiology and biotechnology · 2024Review
- Montmorillonite K-10 catalyzed synthesis of Hantzsch dihydropyridine derivatives from methyl arenesRSC advances · 2024Article
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2 authors at 1 institution in 1 country.
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Abstract
Urease, a nickel-dependent enzyme, has a powerful catalytic activity to decompose urea into ammonia via hydrolysis reaction under mild condition. In the present work, urease was employed for the synthesis of two series of polyhydroquinoline and polyhydroacridine derivatives via one-pot condensation of the ammonia generated in situ from urea, aryl aldehydes, and dimedone or ethyl acetoacetate (i.e., Hantzsch-type reaction) in water under mild green condition. The valuable features of this enzymatic method are mild reaction conditions, short reaction times, wide substrate toleration, and high yield of products. The present work provides a novel enzymatic catalysis to synthesize polyhydroquinolines and polyhydroacridines and expands the application of urease in organic synthesis.
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