Evidence map›Paper›PMID 32507955›Full record

ArticleJournal of industrial microbiology & biotechnology2020

Cytochrome P450-mediated N-demethylation of noscapine by whole-cell biotransformation: process limitations and strategies for optimisation.

Luke Richards, Ailsa Jarrold, Tim Bowser, Geoffrey W Stevens, Sally L Gras

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Molecules (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luke RichardsDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
Ailsa JarroldSun Pharmaceutical Industries Ltd, Princes Highway, Port Fairy, VIC, 3281, Australia.
Tim BowserImpact Science Consulting, Unit 2/52 Swanston St, Heidelberg Heights, VIC, 2081, Australia.
Geoffrey W StevensDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
Sally L GrasDepartment of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia. sgras@unimelb.edu.au.ORCID http://orcid.org/0000-0002-4660-1245
University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 enzymes catalyse reactions of significant industrial interest but are underutilised in large-scale bioprocesses due to enzyme stability, cofactor requirements and the poor aqueous solubility and microbial toxicity of typical substrates and products. In this work, we investigate the potential for preparative-scale N-demethylation of the opium poppy alkaloid noscapine by a P450

Indexed as

BiotransformationBacillus megateriumCatalysisComputer SimulationCyclodextrinsCytochrome P-450 Enzyme SystemDemethylationEscherichia coliIndustrial MicrobiologyMutationNoscapineOrganic ChemicalsOxidation-ReductionPolymersSolubilitySolventsCyclodextrinsCytochrome P-450 Enzyme SystemNoscapineOrganic ChemicalsPolymersSolventsBacillus megateriumBiphasicCyclodextrinMass transferP450BM3

Identifiers

PMID32507955
OpenAlexW3033319469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.