Evidence map›Paper›PMID 32507928›Full record

ArticleJournal of molecular neuroscience : MN2020

Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy.

Andreza Hoepers, Adriano Alberti, Viviane Freiberger, Letícia Ventura, Leoberto Ricardo Grigollo, Cristina Salar Andreu, Bruna Becker da Silva, Daniel Fernandes Martins, Rudy José Nodari Junior, Emilio L Streck and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Beneficial Role of Exercise in the Modulation ofAntioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Andreza HoepersResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Adriano AlbertiResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil. adrianoalberti90@hotmail.com.ORCID http://orcid.org/0000-0003-0313-0380
Viviane FreibergerResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Letícia VenturaResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Leoberto Ricardo GrigolloResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Cristina Salar AndreuCEU Cardenal Herrera University, Valencia, Spain.
Bruna Becker da SilvaResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Daniel Fernandes MartinsResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Rudy José Nodari JuniorDepartment of Physical Education, University of West Santa Catarina, Joaçaba, Brazil.
Emilio L StreckLaboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
Clarissa M ComimResearch Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
Universidade do Sul de Santa Catarina · BRUniversidad Cardenal Herrera CEU · ESUniversidade do Oeste de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a condition caused by an amendment to the X chromosome, inherited as a recessive trait, and affects 1:3500 live births, especially males. Low-intensity exercise is known to decrease certain parameters associated with muscular degeneration in animal models of progressive muscular dystrophies. In the present study, 28-day-old male mdx and wild-type (wild) mice were used. The animals were subjected to a low-intensity physical exercise protocol for 8 weeks. It was found that this protocol was able to reduce oxidative stress in muscle tissue and in most of the CNS structures analyzed, with a significant increase in antioxidant activity in all analyzed structures. It is thus possible to infer that this exercise protocol was able to reduce oxidative stress and improve the energy metabolism in brain tissue and in the gastrocnemius muscle of animals with DMD.

Indexed as

AnimalsExercise TherapyMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, DuchenneOxidative StressPhysical Conditioning, AnimalAnimalDuchenne muscular dystrophyMuscleOxidative stressPhysical exercise

Identifiers

PMID32507928
OpenAlexW3033938562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.