ArticleJournal of atherosclerosis and thrombosis2020
Urinary Stones and Risk of Coronary Heart Disease and Stroke: the Japan Public Health Center-Based Prospective Study.
Article in Journal of atherosclerosis and thrombosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Effects of rosuvastatin and atorvastatin treatment on ET-1, ADMA, and safety efficacy in elderly patients with coronary heart disease combined with hyperlipidemia.Open life sciences · 2026Article
- Elevation of urinary alpha-1-antitrypsin and transferrin excretion in children of patients with nephrolithiasis.Asian biomedicine : research, reviews and news · 2025Article
- Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones.Diseases (Basel, Switzerland) · 2025Article
- Risks of Carotid Artery Stenosis and Atherosclerotic Cardiovascular Disease in Patients with Calcium Kidney Stone: Assessment of Systemic Inflammatory Biomarkers.Journal of personalized medicine · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimEvidence is lacking about whether urinary stones are associated with the subsequent risk of cardiovascular diseases. Herein, we investigated the association between history of urinary stones and the risk of coronary heart disease (CHD) and stroke among middle-aged Japanese.
methodsThis cohort study included 89,037 Japanese men and women (45-74 years) registered in the Japan Public Health Center-based prospective study. Cox proportional hazard models were used to calculate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for incident CHD and stroke among Japanese adults with a self-reported history of urinary stones compared with those without it. The following covariates were included in the regression models: age, sex, area, body mass index, and histories of hypertension, diabetes, hyperlipidemia, smoking habit, alcohol intake, and physical activity.
resultsIn total, 1.31% of Japanese adults reported a positive history of urinary stones. Throughout a median follow-up period of 12 years, 1.16% of Japanese adults developed CHD, and 4.96% developed stroke. No associations were detected between history of urinary stones and the risk of CHD (HR 1.04; 95% CI: 0.64-1.67), stroke (HR 0.92; 95% CI: 0.71-1.20), or total CVD (HR 0.95; 95% CI: 0.75-1.19). Younger urinary stone formers (45-59 years) tended to have a higher, though statistically insignificant, risk of CHD than older urinary stone formers (60-74 years): [(HR 1.15; 95% CI: 0.61-2.15) versus (HR 0.83; 95% CI: 0.40-1.76)], respectively.
conclusionThe history of urinary stones was shown to be not associated with the risk of CVD among Japanese adults.
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