Trial reportJournal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
Vitamin D Supplementation Improves Health-Related Quality of Life and Physical Performance in Children with Sickle Cell Disease and in Healthy Children.
Trial report in Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04662476 (Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital), which is not on this map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital: A Randomised Clinical Trial
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Measurement of fatigue in sickle cell disease: a systematic review of fatigue measures.Orphanet journal of rare diseases · 2025Pooled it
- Pooled it
- The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.Nutrients · 2021Pooled it
- The role of serum levels of vitamin D in children's muscle strength: A systematic review.Clinics (Sao Paulo, Brazil) · 2021Pooled it
- Safety and efficacy of monthly high-dose vitamin DEuropean journal of pediatrics · 2024Trial
- Physical Activity and Physical Fitness in Children and Adolescents Diagnosed With Sickle Cell Disease: A Scoping Review.American journal of lifestyle medicine · 2026Review
- Vitamin D deficiency and fatigue in children: an overlooked but modifiable factor?World journal of pediatrics : WJP · 2025Article
- Association Between Health-Related Physical Fitness and Depressive Symptoms in Chinese Adolescents: A Nationwide Cross-Sectional Study Under the Healthy China Initiative.Neuropsychiatric disease and treatment · 2025Article
- High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling.Research square · 2024Article
- Review
- Review
- Skeletal Muscle Measurements in Pediatric Hematology and Oncology: Essential Components to a Comprehensive Assessment.Children (Basel, Switzerland) · 2023Review
- Hypothesis: Low Vitamin A and D Levels Worsen Clinical Outcomes When Children with Sickle Cell Disease Encounter Parvovirus B19.Nutrients · 2022Article
- Vitamin D level in relation to depression symptoms during adolescence.Child and adolescent psychiatry and mental health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionNo study determined if vitamin D supplementation improves health-related quality of life (HRQL) using pediatric Patient-Reported Outcomes Measurement Information System or physical functioning in type SS sickle cell disease (HbSS).
methodSubjects with HbSS (n = 21) and healthy subjects (n = 23) were randomized to daily oral doses (4,000 vs. 7,000 IU) of cholecalciferol (vitamin D
resultsIn subjects with HbSS, significant reductions in pain, fatigue, and depressive symptoms and improved upper-extremity function were observed. In healthy subjects, significant reductions in fatigue and improved upper-extremity function were observed. Significant improvements in peak power and dorsiflexion isometric maximal voluntary contraction torques were observed in both groups. In subjects with HbSS, improved plantar flexion isometric maximal voluntary contraction torques were observed. Both groups saw significant improvement in their total Bruininks-Oseretsky Test of Motor Proficiency score. DISCUSSION: Daily high-dose vitamin D supplementation for African American children with and without HbSS improved HRQL and physical performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.