ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Microglial Density Alters Measures of Axonal Integrity and Structural Connectivity.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
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- Article
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- Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors.Diagnostics (Basel, Switzerland) · 2021Article
- Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Diffusion microstructure alterations in subcortical gray matter are associated with cognitive and motor performance in Parkinson's disease: a pilot study.Frontiers in neurologyArticle
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5 authors at 1 institution in 1 country.
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Abstract
Diffusion tensor imaging (DTI) has fundamentally transformed how we interrogate diseases and disorders of the brain in neuropsychiatric illness. DTI and recently developed multicompartment diffusion-weighted imaging (MC-DWI) techniques, such as NODDI (neurite orientation dispersion and density imaging), measure diffusion anisotropy presuming a static neuroglial environment; however, microglial morphology and density are highly dynamic in psychiatric illness, and how alterations in microglial density might influence intracellular measures of diffusion anisotropy in DTI and MC-DWI brain microstructure is unknown. To address this question, DTI and MC-DWI studies of murine brains depleted of microglia were performed, revealing significant alterations in axonal integrity and fiber tractography in DTI and in commonly used MC-DWI models. With accumulating evidence of the role of microglia in neuropsychiatric illness, our findings uncover the unexpected contribution of microglia to measures of axonal integrity and structural connectivity and provide unanticipated insights into the potential influence of microglia in diffusion imaging studies of neuropsychiatric disease.
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