ReviewBiological psychiatry2020
Electroencephalography and Event-Related Potential Biomarkers in Individuals at Clinical High Risk for Psychosis.
Review in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- EEG-Based Measures in At-Risk Mental State and Early Stages of Schizophrenia: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- The Effect of Accelerated Continuous Theta Burst Stimulation on Weight Loss in Overweight Individuals With Schizophrenia: A Double-Blind, Randomized, Sham-Controlled Clinical Trial.Schizophrenia bulletin · 2024Trial
- Abnormal emotional intensity processing in individuals at clinical high risk for psychosis: evidence from event-related potentials.European archives of psychiatry and clinical neuroscience · 2026Article
- Corollary Discharge Dysfunction to Inner Speech and its Relationship to Auditory Verbal Hallucinations in Patients with Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.Biological psychiatry · 2026Article
- Eye Movement Abnormalities During the Gaze Perception Task in Individuals With Clinical High Risk for Psychosis: A Discriminant Analysis With Hidden Markov Models.Schizophrenia bulletin · 2026Article
- Volume and Tempo: Cortical Excitability and Trial-to-Trial Consistency of Auditory Responses Distinguish Psychosis Biotypes.Research square · 2026Article
- Loss of regional theta differentiation in TMS-EEG response marks network dysfunction in psychosis risk.Translational psychiatry · 2026Article
- Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2026Article
- Mental time travel and insight in schizophrenia.Psychological medicine · 2025Review
- Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms.medRxiv : the preprint server for health sciences · 2025Article
- Deep learning approach for automatic assessment of schizophrenia and bipolar disorder in patients using R-R intervals.PLoS computational biology · 2025Article
- Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia.BMC psychiatry · 2025Article
- The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures.Schizophrenia (Heidelberg, Germany) · 2025Article
- Advancements and Future Directions in Prevention Based on Evaluation for Individuals With Clinical High Risk of Psychosis: Insights From the SHARP Study.Schizophrenia bulletin · 2025Review
- Neurocognitive Deficits in Individuals at Ultra-High-Risk for Psychosis: An Overview of Systematic Reviews.Iranian journal of psychiatry · 2025Review
- Intraindividual Variability of Event-Related Potentials in Psychosis: A Registered Report.Biological psychiatry global open science · 2025Article
- Neurobiology of schizophrenia.Current opinion in neurobiology · 2024Review
- Temporal imprecision of phase coherence in schizophrenia and psychosis-dynamic mechanisms and diagnostic marker.Molecular psychiatry · 2024Review
- A role for retro-splenial cortex in the task-related P3 network.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Clinical outcomes vary among youths at clinical high risk for psychosis (CHR-P), with approximately 20% progressing to full-blown psychosis over 2 to 3 years and 30% achieving remission. Recent research efforts have focused on identifying biomarkers that precede psychosis onset and enhance the accuracy of clinical outcome prediction in CHR-P individuals, with the ultimate goal of developing staged treatment approaches based on the individual's level of risk. Identifying such biomarkers may also facilitate progress toward understanding pathogenic mechanisms underlying psychosis onset, which may support the development of mechanistically informed early interventions for psychosis. In recent years, electroencephalography-based event-related potential measures with established sensitivity to schizophrenia have gained traction in the study of CHR-P and its clinical outcomes. In this review, we describe the evidence for event-related potential abnormalities in CHR-P and discuss how they inform our understanding of information processing deficits as vulnerability markers for emerging psychosis and as indicators of future outcomes. Among the measures studied, P300 and mismatch negativity are notable because deficits predict conversion to psychosis and/or CHR-P remission. However, the accuracy with which these and other measures predict outcomes in CHR-P has been obscured in the prior literature by the tendency to only report group-level differences, underscoring the need for inclusion of individual predictive accuracy metrics in future studies. Nevertheless, both P300 and mismatch negativity show promise as electrophysiological markers of risk for psychosis, as target engagement measures for clinical trials, and as potential translational bridges between human studies and animal models focused on novel drug development for early psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.