ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2020
Gene-environment interaction: New insights into perceived parenting and social anxiety among adolescents.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 48 citations in OpenAlex.
- The impact of physical activity on adolescent social anxiety: a growth curve model analysis.Frontiers in psychology · 2026Article
- Eye-tracking evidence of an association between social anxiety and avoidance of threatening faces in healthy women.Frontiers in psychiatry · 2026Article
- A Proton Magnetic Resonance Spectroscopy (International journal of molecular sciences · 2025Article
- Effects of Parental Attitudes in Childhood on Depressive Symptoms Through Trait Anxiety and Negative Life Events in Adult Volunteers.Neuropsychiatric disease and treatment · 2025Article
- Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases.Journal of translational medicine · 2023Article
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- The Interaction BetweenFrontiers in psychiatry · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
backgroundSocial anxiety symptoms (SAS) are among the most common mental health problems during adolescence, and it has been shown that parenting influences the adolescent's level of social anxiety. In addition, it is now widely assumed that most mental health problems, including social anxiety, originate from a complex interplay between genes and environment. However, to date, gene-environment (G × E) interactions studies in the field of social anxiety remain limited. In this study, we have examined how 274 genes involved in different neurotransmission pathways interact with five aspects of perceived parenting as environmental exposure (i.e., support, proactive control, psychological control, punitive control, and harsh punitive control) to affect SAS during adolescence.
methodsWe have applied an analytical technique that allows studying genetic information at the gene level, by aggregating data from multiple single-nucleotide-polymorphisms within the same gene and by taking into account the linkage disequilibrium structure of the gene. All participants were part of the STRATEGIES cohort of 948 Flemish adolescents (mean age = 13.7), a population-based study on the development of problem behaviors in adolescence. Relevant genes were preselected based on prior findings and neurotransmitter-related functional protein networks.
resultsThe results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence. Isolated polymorphisms in these genes have been related to anxiety and related disorders in earlier work.Conclusions: Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.
conclusionsTaken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.
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