ArticleCirculation research2020
GRK5 Controls SAP97-Dependent Cardiotoxic β
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Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- The beta1-adrenergic receptor in the heart.Cell death discovery · 2025Review
- Cardiac β2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connective tissue growth factor in cardiac fibrosis and diastolic dysfunction.Function (Oxford, England) · 2025Article
- Longevity mechanisms in cardiac aging: exploring calcium dysregulation and senescence.Biogerontology · 2025Review
- Associations between functional autoantibodies targeting GPCRs, antinuclear antibodies, and inflammatory cytokines TNF-α: a cross-sectional study of 19,810 individuals.Frontiers in immunology · 2025Article
- Review
- G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure.JACC. Basic to translational science · 2024Article
- Differential Downregulation of βJournal of the American Heart Association · 2024Article
- Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.Acta pharmacologica Sinica · 2023Article
- Autonomic control of ventricular function in health and disease: current state of the art.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart.JACC. Basic to translational science · 2023Article
- Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics.Science advances · 2023Article
- Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes.Cell communication and signaling : CCS · 2022Article
- Epac: A Promising Therapeutic Target for Vascular Diseases: A Review.Frontiers in pharmacology · 2022Review
- The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.Physiological reports · 2021Article
- Review
- Adaptive versus maladaptive cardiac remodelling in response to sustained β-adrenergic stimulation in a new 'ISO on/off model'.PloS one · 2021Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 2 countries.
Bing XuFrom the VA Northern California Health Care System, Mather, CA (B.X., Y.K.X.).
Minghui LiDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Ying WangDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Meimi ZhaoDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Stefano MorottiDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Qian ShiDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Qingtong WangDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Federica BarbagalloDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Jian-Peng TeohDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Gopireddy R ReddyDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Elizabeth F BayneDepartment of Chemistry, University of Wisconsin-Madison (E.F.B., Y.G.).
Yongming LiuDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Ao ShenDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Jose L PuglisiDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Ying GeDepartment of Chemistry, University of Wisconsin-Madison (E.F.B., Y.G.).
Ji LiDepartment of Surgery, University of South Florida, Tampa (J.L.).
Eleonora GrandiDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Madeline Nieves-CintronDepartment of Pharmacology, University of California at Davis (B.X., M.L., Y.W., M.Z., S.M., Q.S., Q.W., F.B., J.-P.T., G.R.R., Y.L., A.S., J.L.P., E.G., M.N.-C., Y.K.X.).
Yang K XiangFrom the VA Northern California Health Care System, Mather, CA (B.X., Y.K.X.).
University of California, Davis · USUniversity of Wisconsin–Madison · USVA Northern California Health Care System · USMinistry of Education of the People's Republic of China · CNNanjing Medical University · CNShanghai University · CNUniversity of South Florida · US
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1MSex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0MInsulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4MMolecular Regulation of cardiac adrenergic signalingR01HL147263 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2019 to 2022
$1.7MCardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6MNovel mechanism on subpopulation-dependent biased GPCR signaling in neuronsR01GM129376 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2018 to 2021
$1.6MModeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722kModeling of subcellular signaling crosstalk in failing myocytesK99HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2018 to 2019
$237kMolecular mechanisms of Insulin resistance under chronic stressI01BX002900 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI XIANG, YANG K · 2016 to 2021
–BLRD VA I01 BX002900NHLBI NIH HHS K99 HL138160NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL127764NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL147263NIGMS NIH HHS R01 GM129376
Abstract
rationaleCardiotoxic β
objectiveWe aim to elucidate the dynamics of β METHODS AND
resultsThe integrity of cardiac β
conclusionsThese data reveal a critical role of SAP97 in maintaining the integrity of cardiac β
Indexed as
AnimalsApoptosisbeta-Arrestin 1Calcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedCyclic AMP-Dependent Protein KinasesDiscs Large Homolog 1 ProteinDisease Models, AnimalExcitation Contraction CouplingG-Protein-Coupled Receptor Kinase 5Guanine Nucleotide Exchange FactorsHeart FailureHumansMaleMice, Inbred C57BLMice, KnockoutAdrb1 protein, mouseArrb1 protein, mousebeta-Arrestin 1Calcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP-Dependent Protein KinasesDiscs Large Homolog 1 ProteinDlg1 protein, mouseEpac protein, mouseG-Protein-Coupled Receptor Kinase 5Grk5 protein, mouseGuanine Nucleotide Exchange FactorsReceptors, Adrenergic, beta-1calmodulinheart failuremyocardiummyocyte, cardiacsignaling pathways
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.