ArticleHypertension (Dallas, Tex. : 1979)2020
CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean
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Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Glucose-6-Phosphate Dehydrogenase Modifies the Impact of Glucose on Arterial Aging in A Sex-Specific Manner.Journal of the American Heart Association · 2026Article
- Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADPFree radical biology & medicine · 2025Review
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- Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease.npj metabolic health and disease · 2025Review
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- Characterization of a novel variant in KCNJ16, encoding KPhysiological reports · 2024Article
- Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats.The Journal of biological chemistry · 2024Article
- Establishment and Application of a Novel Genetic Detection Panel for SNPs in Mongolian Gerbils.Genes · 2024Article
- The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia.JVS-vascular science · 2024Article
- Application and perspective of CRISPR/Cas9 genome editing technology in human diseases modeling and gene therapy.Frontiers in genetics · 2024Review
- G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall.International journal of molecular sciences · 2023Article
- Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension.Vascular pharmacology · 2023Article
- The use of new CRISPR tools in cardiovascular research and medicine.Nature reviews. Cardiology · 2022Review
- Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.Vascular pharmacology · 2022Article
- Recent Advances in the Production of Genome-Edited Rats.International journal of molecular sciences · 2022Review
- Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency.Pharmacology & therapeutics · 2021Review
- G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.American journal of physiology. Heart and circulatory physiology · 2021Article
- The Controversial Role of Glucose-6-Phosphate Dehydrogenase Deficiency on Cardiovascular Disease: A Narrative Review.Oxidative medicine and cellular longevity · 2021Review
- Does the Mediterranean G6PD S188F Polymorphism Confer Vascular Protection?: A Novel Rat Model OfferingHypertension (Dallas, Tex. : 1979) · 2020Article
- Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features.Pulmonary circulationArticle
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Authors and funding
12 authors at 5 institutions in 1 country.
Atsushi KitagawaFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
Igor KizubFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
Christina JacobFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
Kevin MichaelFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora (A.D., J.A.R.).
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora (A.D., J.A.R.).
Michael GrzybowskiDepartment of Physiology, Medical College of Wisconsin, Milwaukee (M.G., A.M.G.).
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee (M.G., A.M.G.).
Petra RocicFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
Rakhee GupteRaadysan Biotech, Inc, Fishkill, NY (R.G.).
Joseph M MianoDepartment of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University (J.M.M.).
Sachin A GupteFrom the Department of Pharmacology, New York Medical College, Valhalla (A.K., I.K., C.J., K.M., P.R., S.A.G.).
New York Medical College · USMedical College of Wisconsin · USUniversity of Colorado Anschutz Medical Campus · USAugusta University · USJan Biotech (United States) · US
Funding
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MRegulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5MRegulation and Function of SRF in Vascular PathiobiologyR01HL147476 · NHLBI · UNIVERSITY OF ROCHESTER · PI MIANO, JOSEPH M · 2019 to 2022
$2.1MRegulation of Vascular Smooth Muscle Calcium by NADPH RedoxR01HL085352 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI GUPTE, SACHIN A · 2008 to 2012
$1.9MNHLBI NIH HHS R01 HL085352NHLBI NIH HHS R01 HL132574NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL147476NHLBI NIH HHS R01 HL148151
Abstract
Epidemiological studies suggest that individuals in the Mediterranean region with a loss-of-function, nonsynonymous single nucleotide polymorphism (S188F), in glucose-6-phosphate dehydrogenase (
Indexed as
Genetic Predisposition to DiseaseHeart Disease Risk FactorsAnimalsCardiovascular DiseasesClustered Regularly Interspaced Short Palindromic RepeatsGlucosephosphate DehydrogenaseModels, GeneticPolymorphism, Single NucleotideRatsGlucosephosphate Dehydrogenaseglycolysishypertensionpentose phosphate pathwayratsstiffness
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.