ArticleCirculation. Heart failure2020
Inflammation and Circulating Natriuretic Peptide Levels.
Article in Circulation. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 99 citations in OpenAlex.
- Venous thromboembolism and bleeding in cancer patients: role of inflammatory and cardiac biomarkers.European heart journal · 2026Trial
- Restrictive versus standard intravenous fluid therapy and NTproBNP in ICU patients with septic shock - a sub-study of the randomised CLASSIC trial.BMC anesthesiology · 2026Trial
- Levosimendan for postoperative subclinical heart failure after noncardiac surgery: a randomized, double-blinded, phase III trial.Nature communications · 2025Trial
- Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation.BMC cardiovascular disorders · 2021Trial
- Trial
- Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex-Differential Proteins and Candidate Therapeutic Targets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Natriuretic Peptides as Multisystem Regulators: From Clinical Biomarkers to Therapeutic Targets in Cardio-immunology.Cardiovascular drugs and therapy · 2026Review
- Use of Natriuretic Peptides in Critically Ill Patients: A Narrative Review.Journal of clinical medicine · 2026Review
- Article
- An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts.Age and ageing · 2026Article
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- Low ICU Admission and Excellent Outcomes in MIS-C: A Swedish Study From an Open Society.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- The Investigation of Plasma Natriuretic Peptide as Inflammatory Biomarker Predictor in Coronary Heart Disease Patients With Dry Eye Disease: A Case-Control Study.International journal of inflammation · 2026Article
- Rapid responses of catecholamines, natriuretic peptides and inflammatory markers to acute type B aortic dissection (NeuroendOcrine horMone release in acute type b Aortic Dissection [NOMAD] Study).JVS-vascular science · 2026Article
- Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2025Article
- Dynamics of the Novel Cardiac Biomarkers sST2, H-FABP, GDF-15 and suPAR in HFrEF Patients Undergoing Heart Failure Therapy, a Pilot Study.Journal of clinical medicine · 2025Article
- Natriuretic peptides as novel regulators of dendritic cells-mediated inflammation.Cellular and molecular life sciences : CMLS · 2025Article
- Cardiac biomarkers for risk stratification in newly diagnosed high-risk multiple myeloma in the GMMG-CONCEPT trial.Cardio-oncology (London, England) · 2025Article
- Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort.European journal of heart failure · 2025Article
- Interrelationships Between Plasma Levels of Brain Natriuretic Peptide and Prolonged Symptoms Due to Long COVID.Journal of clinical medicine · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundNPs (natriuretic peptides) are cardiac-derived hormones that promote natriuresis, diuresis, and vasodilation. Preclinical evidence suggests that nonhemodynamic triggers for NP release exist, with a few studies implicating inflammatory stimuli. We examined the association between inflammation and NP levels in humans.
methodsThe associations between inflammation and NP levels were examined in 3 independent studies. First, in 5481 MESA (Multi-Ethnic Study of Atherosclerosis) participants, the cross-sectional (exam 1) and longitudinal (exams 1 to 3) associations between circulating IL6 (interleukin-6) and NT-proBNP (N terminal pro B-type natriuretic peptide) levels were examined in multivariable-adjusted models. Second, in a prospective study of 115 healthy individuals, changes in NP levels were quantified following exposure to lipopolysaccharide as an inflammatory stimulus. Third, in 13 435 hospitalized patients, the association between acute inflammatory conditions and circulating NP levels was assessed using multivariable-adjusted models.
resultsAt the baseline MESA exam, each 1-unit higher natural log IL6 was associated with 16% higher NT-proBNP level ([95% CI, 10%-22%];
conclusionsInflammation appears to be associated with NP release. Interpretation of NP levels should therefore take into account inflammatory conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.