ArticleJournal of diabetes science and technology2021
Unintended Consequence of High-Dose Vitamin C Therapy for an Oncology Patient: Evaluation of Ascorbic Acid Interference With Three Hospital-Use Glucose Meters.
Article in Journal of diabetes science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial.Critical care (London, England) · 2022Trial
- Review
- An in-vitro study to characterise analytical interference caused by sodium ascorbate with point-of-care measurement of lactate and glucose.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Determination of the Precision of Glucometers Used in Saudi Arabia.Sensors (Basel, Switzerland) · 2025Article
- Traditional Interference Experiments vs. Method Comparison Interference Experiments.Journal of diabetes science and technology · 2023Article
- Interferences With CGM Systems: Practical Relevance?Journal of diabetes science and technology · 2022Article
- Antioxidant-Induced Pseudohyperglycemia Due to Interference of Measurements by Blood Glucose Monitors.Journal of diabetes science and technology · 2021Article
- Pseudohyperglycemia Secondary to High-Dose Intravenous Vitamin C Managed as Diabetic Ketoacidosis: An Endocrinological Catastrophe.AACE clinical case reportsArticle
- Artifactual Hypoglycemia Masquerading as a Medical Emergency: A Diagnostic Pitfall of High-Dose Vitamin C.AACE endocrinology and diabetesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of high-dose vitamin C in cancer care has offered promising results for some patients. However, the intravenous (IV) doses used for these patients can reach concentrations that interfere with some strip-based glucose meters. We characterized the impact of vitamin C interference, from standard to the very high doses used for some cancer protocols, using three different hospital-use glucose meters. For two of the three devices tested, increasing concentrations of ascorbic acid caused false elevations in the glucose measurements. The third glucose meter did not provide inaccurate results, regardless of the vitamin C concentration present. Rather, above a certain threshold, the device generated error messages and no results could be obtained.
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Registered trials
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