Evidence map›Paper›PMID 32506744›Full record

Trial reportBrain and behavior2020

Altered activation in sensorimotor network after applying rTMS over the primary motor cortex at different frequencies.

Xiaoyu Wang, Lingyu Li, Wei Wei, Tingting Zhu, Guo-Feng Huang, Xue Li, Hui-Bin Ma, Yating Lv

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoyu WangInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.ORCID 0000-0002-5628-9531
Lingyu LiInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Wei WeiInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Tingting ZhuInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Guo-Feng HuangSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Xue LiSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Hui-Bin MaSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Yating LvInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.ORCID 0000-0002-5547-3361

Funding

National Key R&D Program of China No. 2017YFC1310000National Natural Science Foundation of China 81301210National Natural Science Foundation of China 81771911
6 · The paper itself

Abstract

introductionRepetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) can modulate brain activity both in the stimulated site and remote brain areas of the sensorimotor network. However, the modulatory effects of rTMS at different frequencies remain unclear. Here, we employed finger-tapping task-based fMRI to investigate alterations in activation of the sensorimotor network after the application of rTMS over the left M1 at different frequencies. MATERIALS AND

methodsForty-five right-handed healthy participants were randomly divided into three groups by rTMS frequency (HF, high-frequency, 3 Hz; LF, low-frequency, 1 Hz; and SHAM) and underwent two task-fMRI sessions (RH, finger-tapping with right index finger; LH, finger-tapping with left index finger) before and after applying rTMS over the left M1. We defined regions of interest (ROIs) in the sensorimotor network based on group-level activation maps (pre-rTMS) from RH and LH tasks and calculated the percentage signal change (PSC) for each ROI. We then assessed the differences of PSC within HF or LF groups and between groups.

resultsApplication of rTMS at different frequencies resulted in a change in activation of several areas of the sensorimotor network. We observed the increased PSC in M1 after high-frequency stimulation, while we detected the reduced PSC in the primary sensory cortex (S1), ventral premotor cortex (PMv), supplementary motor cortex (SMA), and putamen after low-frequency stimulation. Moreover, the PSC in the SMA, dorsal premotor cortex (PMd), and putamen in the HF group was higher than in the LF group after stimulation.

conclusionOur findings suggested that activation alterations within sensorimotor network are dependent on the frequency of rTMS. Therefore, our findings contribute to understanding the effects of rTMS on brain activation in healthy individuals and ultimately may further help to suggest mechanisms of how rTMS could be employed as a therapeutic tool.

Indexed as

Motor CortexTranscranial Magnetic StimulationBrain MappingFunctional LateralityHandHumansfinger-tapping taskfunctional MRIprimary motor cortexrepetitive transcranial magnetic stimulationsensorimotor network

Identifiers

PMID32506744
PMCPMC7375128

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.