ArticleJournal of diabetes investigation2021
Low-density lipoprotein cholesterol : high-density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Association of total cholesterol to high-density lipoprotein cholesterol ratio with diabetes risk: a retrospective study of Chinese individuals.Scientific reports · 2025Article
- Potential Impact of Choline Alphoscerate on Depressive Symptoms in Association with Insulin Resistance in Elderly Patients with Type 2 Diabetes.Journal of clinical medicine · 2025Article
- Lipids as the link between central obesity and diabetes: perspectives from mediation analysis.BMC endocrine disorders · 2024Article
- Development, validation and visualization of a web-based nomogram for predicting risk of new-onset diabetes after percutaneous coronary intervention.Scientific reports · 2024Article
- Higher LDL-C/HDL-C Ratio Is Associated with Elevated HbA1c and Decreased eGFR Levels and Cardiac Remodeling in Elderly with Hypercholesterolemia.Journal of cardiovascular development and disease · 2024Article
- Updates on dyslipidemia in patients with diabetes.Journal of diabetes investigation · 2023Article
- Development and validation of a nomogram prediction model for hypertension-diabetes comorbidity based on chronic disease management in the community.Lipids in health and disease · 2023Article
- Association of four lipid-derived indicators with the risk of developing type 2 diabetes: a Chinese population-based cohort study.Lipids in health and disease · 2023Article
- Article
- Traditional and Non-traditional Lipid Profiles in Bosnian Patients with Probable Alzheimer's Disease and Vascular Dementia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China.Cardiovascular diabetology · 2022Article
- Difference in the Standard and Novel Lipid Profile Parameters Between Patients With Alzheimer's Disease and Vascular Dementia Stratified by the Degree of Cognitive Impairment.Materia socio-medica · 2022Article
- Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults.Lipids in health and disease · 2022Observational
- The predictive value of routine laboratory tests for colorectal polyps: a retrospective study.Journal of gastrointestinal oncology · 2022Article
- Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9.Frontiers in endocrinology · 2022Article
- Dysregulated Serum Lipid Metabolism Promotes the Occurrence and Development of Diabetic Retinopathy Associated With Upregulated Circulating Levels of VEGF-A, VEGF-D, and PlGF.Frontiers in medicine · 2021Article
- Low-density lipoprotein cholesterol : high-density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study.Journal of diabetes investigation · 2021Article
- Clinical Features and Optical Coherence Tomography Angiography in Neovascular Age-Related Macular Degeneration and Pachychoroid Neovasculopathy.Journal of vitreoretinal diseasesArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionDyslipidemia plays a critical role in the pathogenesis of metabolic syndrome and diabetes. Evidence has increasingly shown that the ratio of low- to high-density lipoprotein cholesterol (LDL-C/HDL-C) is a novel marker for increased risk of insulin resistance and cardiovascular diseases. However, the correlation between the LDL-C/HDL-C ratio and diabetes risk is rarely reported. This is the first study to investigate the association between the LDL-C/HDL-C ratio and new-onset diabetes in a large community-based cohort. MATERIALS AND
methodsIn this retrospective cohort study, a total of 116,661 adults without baseline diabetes were enrolled. Participants were stratified into four groups based on LDL-C/HDL-C ratio quartiles. The outcome of interest was new-onset diabetes.
resultsDuring a median follow-up period of 2.98 years, 2,681 (2.3%) new diabetes cases were recorded. The total cumulative incidence of diabetes progressively increased alongside LDL-C/HDL-C ratio quartiles (0.31, 0.43, 0.68 and 0.88%, respectively, P-value for trend <0.001). After adjusting for potential confounders, using the lowest quartile of the LDL-C/HDL-C ratio as the reference, the risk of diabetes increased with LDL-C/HDL-C ratio quartiles (P-value for trend <0.001); in particular, from the second to fourth quartile, hazard ratios were 1.18 (95% confidence interval 0.87-1.59), 1.42 (95% confidence interval 1.07-1.90) and 1.92 (95% confidence interval 1.43-2.59), respectively. The results were also robust to challenges in multiple sensitivity analyses.
conclusionsAmong the Chinese population, elevated LDL-C/HDL-C ratio might be an independent risk factor for new-onset diabetes.
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