ReviewCurrent pain and headache reports2020
Gut Microbiome Dysbiosis and Depression: a Comprehensive Review.
Review in Current pain and headache reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT05646784 (Pathophysiological Aspects of the Role of Inflammation and Gut Microbiota in Mood Disorders, and Their Therapeutic Implications in Lebanese Population), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pathophysiological Aspects of the Role of Inflammation and Gut Microbiota in Mood Disorders, and Their Therapeutic Implications in Lebanese Population
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut microbiota variations in patients diagnosed with major depressive disorder-A systematic review.Brain and behavior · 2021Pooled it
- Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial.BMC psychiatry · 2026Trial
- Gut microbial biomarkers for major depressive disorder: a cross-sectional study.Frontiers in cellular and infection microbiology · 2026Article
- The Bidirectional Relationship Between the Gut Microbiome and Mental Health: A Comprehensive Review.Cureus · 2025Review
- Microbiota-gut-brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system.Journal of cellular and molecular medicine · 2024Review
- Alcohol consumption during pregnancy differentially affects the fecal microbiota of dams and offspring.Scientific reports · 2024Article
- Depression Following Acute Coronary Syndrome: A Review.Reviews in cardiovascular medicine · 2023Review
- Role of the gut-brain axis in HIV and drug abuse-mediated neuroinflammation.Advances in drug and alcohol research · 2023Review
- Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review.Antioxidants (Basel, Switzerland) · 2022Review
- Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder.Biomedicines · 2022Article
- Dysbiosis: A Potential Precursor to the Development of a Depressive Disorder.Healthcare (Basel, Switzerland) · 2022Article
- Effect of Caging onMicroorganisms · 2022Article
- The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder.Nutrients · 2022Review
- Potential Role of Epigenetics and Redox Signaling in the Gut-Brain Communication and the Case of Autism Spectrum Disorder.Cellular and molecular neurobiology · 2022Article
- Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder.Nutrients · 2021Review
- Examining the Role of Microbiota in Emotional Behavior: Antibiotic Treatment Exacerbates Anxiety in High Anxiety-Prone Male Rats.Neuroscience · 2021Article
- Article
- The Gut Microbiome and Substance Use Disorder.Frontiers in neuroscience · 2021Review
- Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis Signaling.BioMed research international · 2021Review
- Exploring the Role of Gut Microbiota in Major Depressive Disorder and in Treatment Resistance to Antidepressants.Biomedicines · 2020Article
Corrections and comments
- Retraction · 2023-03-27Duplication of Content through Error by Journal/Publisher · Lack of Approval from Author ·
- Retracted
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe human gut microbiome is involved in a bi-directional communication pathway with the central nervous system (CNS), termed the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to mediate or modulate various central processes through the vagus nerve. The microbiota-gut-brain axis is involved with the production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease. RECENT
findingsThough studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed in the present investigation include an array of basic science studies that clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to humans. The studies presented in this review demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression.
Indexed as
Identifiers
32506238What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.