How CD40L reverse signaling regulates axon and dendrite growth.

Open access · hybridAbstract read

In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.3field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

Infections in the Developing Brain: The Role of the Neuro-Immune Axis.Frontiers in neurology · 2022
Review
CD40L/CD40 bidirectional signaling is a major regulator of neuronal morphology in the developing nervous system.Neural regeneration research · 2021
Article
Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth.Cells · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paulina CarribaSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, Wales. paulina.carriba@gmail.com.ORCID http://orcid.org/0000-0002-6980-2277

Alun M DaviesSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, Wales.

Cardiff University · GB

Funding

Wellcome TrustWellcome Trust grant number 103852

6 · The paper itself

Abstract

CD40-activated CD40L reverse signaling is a major physiological regulator of axon and dendrite growth from developing hippocampal pyramidal neurons. Here we have studied how CD40L-mediated reverse signaling promotes the growth of these processes. Cultures of hippocampal pyramidal neurons were established from Cd40

Indexed as

Signal TransductionAnimalsAxonsButadienesCD40 AntigensCD40 LigandCells, CulturedDendritesHippocampusJNK Mitogen-Activated Protein KinasesMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NitrilesButadienesCD40 AntigensCD40 LigandJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NitrilesProtein Kinase CSyk KinaseU 0126Axon and dendrite developmentCD40c-jun N-terminal kinaseExtracellular signal-regulated kinasesProtein kinase CReverse signalingTyrosine-protein kinase syk

Identifiers

PMID32506167

DOI10.1007/s00018-020-03563-2

PMCPMC7897621

OpenAlexW3032901921

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.