Evidence map›Paper›PMID 32505811›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2020

Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic.

Horng-Ruey Chua, Graeme MacLaren, Lina Hui-Lin Choong, Chang-Yin Chionh, Benjamin Zhi En Khoo, See-Cheng Yeo, Duu-Wen Sewa, Shin-Yi Ng, Jason Chon-Jun Choo, Boon-Wee Teo and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Kidney implications of SARS-CoV2 infection in children.Pediatric nephrology (Berlin, Germany) · 2022
    Review
  6. COVID-19 and Acute Kidney Injury.Critical care clinics · 2022
    Review
  7. Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  8. Article
  9. Review
  10. Observational
  11. Review
  12. Review
  13. Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI.Journal of the American Society of Nephrology : JASN · 2020
    Observational
  14. Review
  15. Management of Acute Kidney Injury in Coronavirus Disease 2019.Advances in chronic kidney disease · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Horng-Ruey ChuaDivision of Nephrology, Department of Medicine, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: horng_ruey_chua@nuhs.edu.sg.
Graeme MacLarenYong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiothoracic Intensive Care Unit, Department of Cardiac, Thoracic & Vascular Surgery, National University Hospital, Singapore.
Lina Hui-Lin ChoongDepartment of Renal Medicine, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore.
Chang-Yin ChionhDepartment of Renal Medicine, Changi General Hospital, Singapore.
Benjamin Zhi En KhooDepartment of Renal Medicine, Tan Tock Seng Hospital, Singapore.
See-Cheng YeoDepartment of Renal Medicine, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Duu-Wen SewaDuke-NUS Medical School, Singapore; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
Shin-Yi NgDuke-NUS Medical School, Singapore; Department of Surgical Intensive Care, Singapore General Hospital, Singapore.
Jason Chon-Jun ChooDepartment of Renal Medicine, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore.
Boon-Wee TeoDivision of Nephrology, Department of Medicine, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Han-Khim TanDepartment of Renal Medicine, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore.
Wen-Ting SiowYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore.
Rohit Vijay AgrawalYong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Anaesthesia, National University Hospital, Singapore.
Chieh-Suai TanDepartment of Renal Medicine, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore.
Anantharaman VathsalaDivision of Nephrology, Department of Medicine, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Rajat TagoreDivision of Renal Medicine, Department of Medicine, Ng Teng Fong General Hospital, Singapore.
Terina Ying-Ying SeowDivision of Renal Medicine, Department of Medicine, Sengkang General Hospital, Singapore.
Priyanka KhatriDivision of Nephrology, Department of Medicine, National University Hospital, Singapore; Fast and Chronic Programmes, Alexandra Hospital, Singapore.
Wei-Zhen HongDivision of Nephrology, Department of Medicine, National University Hospital, Singapore; Fast and Chronic Programmes, Alexandra Hospital, Singapore.
Manish KaushikDepartment of Renal Medicine, Singapore General Hospital, Singapore; Duke-NUS Medical School, Singapore. Electronic address: manish.kaushik@singhealth.com.sg.
National University Hospital · SGSingapore General Hospital · SGDuke-NUS Medical School · SGNational University of Singapore · SGChangi General Hospital · SGNanyang Technological University · SGNg Teng Fong General Hospital · SGSengkang General Hospital · SGTan Tock Seng Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the exponential surge in patients with coronavirus disease 2019 (COVID-19) worldwide, the resources needed to provide continuous kidney replacement therapy (CKRT) for patients with acute kidney injury or kidney failure may be threatened. This article summarizes subsisting strategies that can be implemented immediately. Pre-emptive weekly multicenter projections of CKRT demand based on evolving COVID-19 epidemiology and routine workload should be made. Corresponding consumables should be quantified and acquired, with diversification of sources from multiple vendors. Supply procurement should be stepped up accordingly so that a several-week stock is amassed, with administrative oversight to prevent disproportionate hoarding by institutions. Consumption of CKRT resources can be made more efficient by optimizing circuit anticoagulation to preserve filters, extending use of each vascular access, lowering blood flows to reduce citrate consumption, moderating the CKRT intensity to conserve fluids, or running accelerated KRT at higher clearance to treat more patients per machine. If logistically feasible, earlier transition to intermittent hemodialysis with online-generated dialysate, or urgent peritoneal dialysis in selected patients, may help reduce CKRT dependency. These measures, coupled to multicenter collaboration and a corresponding increase in trained medical and nursing staffing levels, may avoid downstream rationing of care and save lives during the peak of the pandemic.

Indexed as

BetacoronavirusPandemicsAcute Kidney InjuryAnticoagulantsContinuous Renal Replacement TherapyCoronavirus InfectionsCOVID-19Dialysis SolutionsHealth Services Needs and DemandHumansPneumonia, ViralRenal InsufficiencySARS-CoV-2AnticoagulantsDialysis SolutionsAcute kidney injury (AKI)citratescontinuous renal replacement therapy (CRRT)coronavirus 19 disease (COVID-19)dialysis solutionskidney failurenursing staffpandemicsresource managementsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)workload

Identifiers

PMID32505811
PMCPMC7272152
OpenAlexW3033265709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.