Evidence map›Paper›PMID 32505710›Full record

Trial reportJournal of sport and health science2021

Inter-individual differences in the responses to aerobic exercise in Alzheimer's disease: Findings from the FIT-AD trial.

Fang Yu, Dereck Salisbury, Michelle A Mathiason

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of sport and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Standard Deviation of Individual Response for VOSports medicine (Auckland, N.Z.) · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Lifestyle Interventions in Frailty.Advances in experimental medicine and biology · 2025
    Review
  14. Article
  15. Greater physical fitness (Acta physiologica (Oxford, England) · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fang YuAdult and Gerontological Health Cooperative, School of Nursing, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: yuxxx244@umn.edu.
Dereck SalisburyAdult and Gerontological Health Cooperative, School of Nursing, University of Minnesota, Minneapolis, MN 55455, USA.
Michelle A MathiasonAdult and Gerontological Health Cooperative, School of Nursing, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume EffectsR01AG043392 · NIA · UNIVERSITY OF MINNESOTA · PI YU, FANG · 2013 to 2018
$3.2M
NCATS NIH HHS UL1 TR000114NIA NIH HHS R01 AG043392
6 · The paper itself

Abstract

backgroundDespite the strong evidence of aerobic exercise as a disease-modifying treatment for Alzheimer's disease (AD) in animal models, its effects on cognition are inconsistent in human studies. A major contributor to these findings is inter-individual differences in the responses to aerobic exercise, which was well documented in the general population but not in those with AD. The purpose of this study was to examine inter-individual differences in aerobic fitness and cognitive responses to a 6-month aerobic exercise intervention in community-dwelling older adults with mild-to-moderate dementia due to AD.

methodsThis study was a secondary analysis of the Effects of Aerobic Exercise for Treating Alzheimer's Disease (FIT-AD) trial data. Aerobic fitness was measured by the shuttle walk test (SWT), the 6-min walk test (6MWT), and the maximal oxygen consumption (VO

resultsSeventy-eight participants were included in this study (77.4 ± 6.3 years old, mean ± SD; 15.7 ± 2.8 years of education; 41% were female). VO

conclusionThere are true inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise in older adults with mild-to-moderate dementia due to AD. These inter-individual differences likely underline the inconsistent cognitive benefits in human studies.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCognitionEducational StatusExerciseFemaleHumansIndependent LivingMaleOxygen ConsumptionPhysical FitnessSocioeconomic FactorsTime FactorsWalk TestAlzheimer's diseaseCognitionDementiaExercisePhysical activity

Identifiers

PMID32505710
PMCPMC7858037
OpenAlexW3033747695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.