Evidence map›Paper›PMID 32505541›Full record

ReviewRedox biology2020

Oxidative stress pathways of air pollution mediated toxicity: Recent insights.

Roopesh Singh Gangwar, Graham H Bevan, Rengasamy Palanivel, Lopa Das, Sanjay Rajagopalan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Association between PMBMC public health · 2026
    Pooled it
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  6. Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
    Pooled it
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  16. PMiScience · 2026
    Review
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101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roopesh Singh GangwarCardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Graham H BevanCardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Rengasamy PalanivelCardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Lopa DasCardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sanjay RajagopalanCardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: sanjay.rajagopalan@uhhospitals.org.

Funding

Air Pollution and Hypertension: Vascular MechanismsR01ES015146 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2007 to 2018
$4.5M
Environmental Triggers of Cardiometabolic DiseaseR01ES019616 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI BROOK, ROBERT DANIEL, RAJAGOPALAN, SANJAY · 2011 to 2020
$3.0M
NIEHS NIH HHS R01 ES015146NIEHS NIH HHS R01 ES019616
6 · The paper itself

Abstract

Ambient air pollution is a leading environmental cause of morbidity and mortality globally with most of the outcomes of cardiovascular origin. While numerous mechanisms are proposed to explain the link between air pollutants and cardiovascular events, the evidence supports a role for oxidative stress as a critical intermediary pathway in the transduction of systemic responses in the cardiovascular system. Indeed, alterations in vascular function are a critical step in the development of cardiometabolic disorders such as hypertension, diabetes, and atherosclerosis. This review will provide an overview of the impact of particulate and gaseous pollutants on oxidative stress from human and animal studies published in the last five years. We discuss current gaps in knowledge and evidence to date implicating the role of oxidative stress with an emphasis on inhalational exposures. We conclude with the identification of gaps, and an exhortation for further studies to elucidate the impact of oxidative stress in air pollution mediated effects.

Indexed as

Air PollutantsAir PollutionAtherosclerosisCardiovascular DiseasesAnimalsHumansOxidative StressParticulate MatterAir PollutantsParticulate MatterAir pollutionLung inflammationOxidative stressParticulate matterReactive oxygen speciesRedox reaction

Identifiers

PMID32505541
PMCPMC7327965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.