ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
MRSA Transmission in Intensive Care Units: Genomic Analysis of Patients, Their Environments, and Healthcare Workers.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Global insights into MRSA bacteremia: a bibliometric analysis and future outlook.Frontiers in microbiology · 2024Pooled it
- Epidemiologic and Clinical Divergence of MRSA USA100 and USA300 in the United States.Antibiotics (Basel, Switzerland) · 2026Article
- Genome sequencing for prevention of health-care-associated bacterial infections.Nature reviews. Microbiology · 2026Review
- Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage.The Journal of infectious diseases · 2026Article
- A novel and validated 3D-printed method for the consistent and reproducible dry transfer of microorganisms for the determination of antimicrobial surface efficacy.Applied and environmental microbiology · 2025Article
- Tracking Antimicrobial Resistant Organisms Timely: a workflow validation study for successive core-genome SNP-based nosocomial transmission analysis.JAC-antimicrobial resistance · 2025Article
- World Hand Hygiene Day 2025: A perspective from theInfection prevention in practice · 2025Article
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Effects of simulated space environmental conditions on cleanroom microbes.Frontiers in microbiology · 2025Article
- Fecal Carriage of Multidrug-ResistantBioMed research international · 2025Article
- Molecular Characteristics of Community-Acquired Methicillin-ResistantIndian journal of microbiology · 2024Article
- Hand and environmental hygiene: respective roles for MRSA, multi-resistant gram negatives, Clostridioides difficile, and Candida spp.Antimicrobial resistance and infection control · 2024Review
- Article
- Environmental approaches to controlling Clostridioides difficile infection in healthcare settings.Antimicrobial resistance and infection control · 2023Review
- Textiles as fomites in the healthcare system.Applied microbiology and biotechnology · 2023Review
- Article
- Molecular concordance of methicillin-resistantInfection control and hospital epidemiology · 2023Article
- Mitigating hospital-onsetInfection control and hospital epidemiology · 2023Article
- Methicillin ResistantInfection and drug resistance · 2023Review
- Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid-based hospital surface disinfectant.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMethicillin-resistant Staphylococcus aureus (MRSA)-and now USA300 MRSA-is a significant intensive care unit (ICU) pathogen; healthcare worker (HCW) contamination may lead to patient cross-transmission.
methodsFrom September 2015 to February 2016, to study the spread of MRSA, we enrolled HCWs in 4 adult ICUs caring for patients on MRSA contact precautions. Samples were collected from patient body sites and high-touch surfaces in patient rooms. HCW hands, gloves, and personal protective equipment were sampled pre/post-patient encounter. Whole genome sequencing (WGS) was used to compare isolates from patients, HCWs, and environment.
resultsThere were 413 MRSA isolates sequenced (38% USA300, 52% USA100) from 66 patient encounters. Six of 66 HCWs were contaminated with MRSA prior to room entry. Isolates from a single patient encounter were typically either USA100 or USA300; in 8 (12%) encounters both USA300 and USA100 were isolated. WGS demonstrated that isolates from patients, HCWs, and environment often were genetically similar, although there was substantial between-encounter diversity. Strikingly, there were 5 USA100 and 1 USA300 clusters that contained similar strains (<22 single-nucleotide variants [SNVs], with most <10 SNVs) within the cluster despite coming from different encounters, suggesting intra- and inter-ICU spread of strains, that is, 4 of these genomic clusters were from encounters in the same ICU; 5 of 6 clusters occurred within 1 week.
conclusionsWe demonstrated frequent spread of MRSA USA300 and USA100 strains among patients, environment, and HCWs. WGS identified possible spread within and even between ICUs. Future analysis with detailed contact tracing in conjunction with genomic data may further elucidate pathways of MRSA spread and points for intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.